Determinants of DNMT2/TRDMT1 preference for substrates tRNA and DNA during the evolution

Determinants of DNMT2/TRDMT1 preference for substrates tRNA and DNA during the evolution

RNA methyltransferase DNMT2/TRDMT1 is the most conserved member of the DNMT family from bacteria to plants and mammals. In previous studies, we found some determinants for tRNA recognition of DNMT2/TRDMT1, but the preference mechanism of this enzyme for substrates tRNA and DNA remains to be explored...

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Bibliographic Details
Main Authors: Huari Li, Daiyun Zhu, Yapeng Yang, Yunfei Ma, Yong Chen, Pingfang Xue, Juan Chen, Mian Qin, Dandan Xu, Chao Cai, Hongjing Cheng
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:RNA Biology
Subjects:
DNMT2/TRDMT1
tRNA
substrate preference
gene expression
anticancer effect
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2023.2272473
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