Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study
This study examined the relationship between type 2 diabetes and late syphilis. A retrospective analysis was conducted, including 96 syphilis patients with type 2 diabetes and 122 matched non-diabetic syphilis controls. The development of late-stage syphilis and responses to initial treatment were m...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-04-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/42210 |
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| author | Yijie Tang Mengxiao Wu Wenwen Xu Jiajie Yu Dandan Yang Jiaqin Zhang Lingyun Shen Qinghui Xie Qingqiong Luo |
| author_facet | Yijie Tang Mengxiao Wu Wenwen Xu Jiajie Yu Dandan Yang Jiaqin Zhang Lingyun Shen Qinghui Xie Qingqiong Luo |
| author_sort | Yijie Tang |
| collection | DOAJ |
| description | This study examined the relationship between type 2 diabetes and late syphilis. A retrospective analysis was conducted, including 96 syphilis patients with type 2 diabetes and 122 matched non-diabetic syphilis controls. The development of late-stage syphilis and responses to initial treatment were monitored over a 2-year period. Stratified logistic regression was used to assess whether diabetes increased the risk of late syphilis. Differences in initial treatment responses between the 2 groups were evaluated using χ2 tests and Kaplan–Meier curves. The cohort study confirmed that the serological cure rate within 12 months was significantly lower in diabetic syphilis patients. Type 2 diabetes significantly impacts the efficacy of syphilis treatment and is a risk factor for late syphilis.
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| format | Article |
| id | doaj-art-251de28d19db49f4a8ac47b4038cde17 |
| institution | DOAJ |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-251de28d19db49f4a8ac47b4038cde172025-08-20T03:17:31ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-04-0110510.2340/actadv.v105.42210Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort StudyYijie Tang0Mengxiao Wu1Wenwen Xu2Jiajie Yu3Dandan Yang4Jiaqin Zhang5Lingyun Shen6Qinghui Xie7Qingqiong Luo8Department of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Biochemistry, School of Basic medical science, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Skin disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaThis study examined the relationship between type 2 diabetes and late syphilis. A retrospective analysis was conducted, including 96 syphilis patients with type 2 diabetes and 122 matched non-diabetic syphilis controls. The development of late-stage syphilis and responses to initial treatment were monitored over a 2-year period. Stratified logistic regression was used to assess whether diabetes increased the risk of late syphilis. Differences in initial treatment responses between the 2 groups were evaluated using χ2 tests and Kaplan–Meier curves. The cohort study confirmed that the serological cure rate within 12 months was significantly lower in diabetic syphilis patients. Type 2 diabetes significantly impacts the efficacy of syphilis treatment and is a risk factor for late syphilis. https://medicaljournalssweden.se/actadv/article/view/42210diabetessyphiliscohort studyrisk |
| spellingShingle | Yijie Tang Mengxiao Wu Wenwen Xu Jiajie Yu Dandan Yang Jiaqin Zhang Lingyun Shen Qinghui Xie Qingqiong Luo Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study Acta Dermato-Venereologica diabetes syphilis cohort study risk |
| title | Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study |
| title_full | Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study |
| title_fullStr | Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study |
| title_full_unstemmed | Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study |
| title_short | Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study |
| title_sort | type 2 diabetes impacts the efficacy of syphilis treatment and is a risk factor for late syphilis a retrospective cohort study |
| topic | diabetes syphilis cohort study risk |
| url | https://medicaljournalssweden.se/actadv/article/view/42210 |
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