Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure
Background: Infection after craniocerebral operation has always been a very focused problem, and dural closure can reduce perioperative infection by reducing drainage volume and subcutaneous effusion, so how to effectively perform dural closure seems to be a small but not negligible problem. Methods...
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Elsevier
2025-02-01
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| author | Caizhi Ma Zhe Han Shouji Zhang Jia Li Huizhong Chi Qingtong Wang Hongyu Zhao Deze Jia Kailiang Zhang Zichao Feng Hongwei Wang Jie Gong Shilei Ni Gang Li Xueen Li Hao Xue |
| author_facet | Caizhi Ma Zhe Han Shouji Zhang Jia Li Huizhong Chi Qingtong Wang Hongyu Zhao Deze Jia Kailiang Zhang Zichao Feng Hongwei Wang Jie Gong Shilei Ni Gang Li Xueen Li Hao Xue |
| author_sort | Caizhi Ma |
| collection | DOAJ |
| description | Background: Infection after craniocerebral operation has always been a very focused problem, and dural closure can reduce perioperative infection by reducing drainage volume and subcutaneous effusion, so how to effectively perform dural closure seems to be a small but not negligible problem. Methods: We proposed a classification and grading system for dural incisions based on the type and degree of suture, and based on the system, a standardized operation process for ADS (absorbable dural sealant) was developed. Then, we conducted a retrospective study. We divided the included patients into 3 groups. Normalized group follows the ADS standard use process proposed by us, while Empirical group does not meet or only partially meets the ADS standard use process, or uses ADS based on its own experience, and Non-sealant group were patients who did not use ADS. And perioperative infection was used as the primary assessment metric to verify the effectiveness of ADS in blocking the dural membrane, and to try to propose a standardized use plan. Results: A retrospective collection of 383 patients' clinical data was conducted between October 2019 and April 2023 in the Department of Neurosurgery of Qilu Hospital of Shandong University. Of them, 128 belonged to the non-sealant group, 126 to the normalized group, and 129 to the empirical group. In our study, we discovered that, in comparison to the normalized group, postoperative cerebral infection rose by 17.2 % (OR = 2.437, P = 0.004) and 21.9 % (OR = 3.227, P < 0.001), respectively, in the empirical group and non-sealant group. In comparison to the normalized group, the empirical group and non-sealant group experienced a 13.2 % (OR = 1.882, P = 0.037) and 24.8 % (OR = 3.346, P < 0.001) increase in subcutaneous effusion development, respectively. Furthermore, when compared to the normalized group, the empirical group's (β = 48.556, P = 0.003) and non-sealant group's (β = 91.960, P < 0.001) subcutaneous or epidural drainage volume was significantly higher. Conclusions: Correct and standardized use of ADS can improve the watertight suturing of the dura mater and reduce the incidence of postoperative complications such as infection, and is of great significance for perioperative management of neurosurgery. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| spelling | doaj-art-251c0fc97b26410a868231b43c05ddcc2025-01-26T05:04:15ZengElsevierHeliyon2405-84402025-02-01113e41966Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedureCaizhi Ma0Zhe Han1Shouji Zhang2Jia Li3Huizhong Chi4Qingtong Wang5Hongyu Zhao6Deze Jia7Kailiang Zhang8Zichao Feng9Hongwei Wang10Jie Gong11Shilei Ni12Gang Li13Xueen Li14Hao Xue15Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Jinan, Shandong, 250021, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaInstitute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, China; Corresponding authors. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Brain and Brain-Inspired Science; Shandong Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong, 250012, China.Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, China; Corresponding author. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Brain and Brain-Inspired Science; Shandong Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong, 250012, China.Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Institute of Brain and Brain-Inspired Science, Shandong University, Shandong, China; Shandong Key Laboratory of Brain Function Remodeling, Shandong, China; Corresponding author. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Brain and Brain-Inspired Science; Shandong Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong, 250012, China.Background: Infection after craniocerebral operation has always been a very focused problem, and dural closure can reduce perioperative infection by reducing drainage volume and subcutaneous effusion, so how to effectively perform dural closure seems to be a small but not negligible problem. Methods: We proposed a classification and grading system for dural incisions based on the type and degree of suture, and based on the system, a standardized operation process for ADS (absorbable dural sealant) was developed. Then, we conducted a retrospective study. We divided the included patients into 3 groups. Normalized group follows the ADS standard use process proposed by us, while Empirical group does not meet or only partially meets the ADS standard use process, or uses ADS based on its own experience, and Non-sealant group were patients who did not use ADS. And perioperative infection was used as the primary assessment metric to verify the effectiveness of ADS in blocking the dural membrane, and to try to propose a standardized use plan. Results: A retrospective collection of 383 patients' clinical data was conducted between October 2019 and April 2023 in the Department of Neurosurgery of Qilu Hospital of Shandong University. Of them, 128 belonged to the non-sealant group, 126 to the normalized group, and 129 to the empirical group. In our study, we discovered that, in comparison to the normalized group, postoperative cerebral infection rose by 17.2 % (OR = 2.437, P = 0.004) and 21.9 % (OR = 3.227, P < 0.001), respectively, in the empirical group and non-sealant group. In comparison to the normalized group, the empirical group and non-sealant group experienced a 13.2 % (OR = 1.882, P = 0.037) and 24.8 % (OR = 3.346, P < 0.001) increase in subcutaneous effusion development, respectively. Furthermore, when compared to the normalized group, the empirical group's (β = 48.556, P = 0.003) and non-sealant group's (β = 91.960, P < 0.001) subcutaneous or epidural drainage volume was significantly higher. Conclusions: Correct and standardized use of ADS can improve the watertight suturing of the dura mater and reduce the incidence of postoperative complications such as infection, and is of great significance for perioperative management of neurosurgery.http://www.sciencedirect.com/science/article/pii/S2405844025003469Neurosurgical operationAbsorbable dural sealantCerebrospinal fluid leakageIntracranial infectionSubcutaneous effusionApplication strategy |
| spellingShingle | Caizhi Ma Zhe Han Shouji Zhang Jia Li Huizhong Chi Qingtong Wang Hongyu Zhao Deze Jia Kailiang Zhang Zichao Feng Hongwei Wang Jie Gong Shilei Ni Gang Li Xueen Li Hao Xue Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure Heliyon Neurosurgical operation Absorbable dural sealant Cerebrospinal fluid leakage Intracranial infection Subcutaneous effusion Application strategy |
| title | Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure |
| title_full | Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure |
| title_fullStr | Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure |
| title_full_unstemmed | Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure |
| title_short | Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure |
| title_sort | study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure |
| topic | Neurosurgical operation Absorbable dural sealant Cerebrospinal fluid leakage Intracranial infection Subcutaneous effusion Application strategy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025003469 |
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