Modular (universal) CAR-T platforms in vivo: a comprehensive systematic review

Modular (universal) CAR-T platforms in vivo: a comprehensive systematic review

BackgroundModular (universal) CAR T-platforms were developed to combat the limitations of traditional CAR-T therapy, allowing for multiple targeting of tumor-associated antigens and the ability to control CAR-T cell activity. The modular CAR-T platform consists of a universal receptor (signaling mod...

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Bibliographic Details
Main Authors: Afraa Mohammad, Anna Yurina, Tatiana Simonyan, Daniil Chistyakov, Rand Salman, Ksenia Zornikova, Elizaveta Minina, Apollinariya Bogolyubova
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
modular CAR T
universal CAR T
xenograft model
pre-clinical study
systematic review
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1409665/full
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