First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer

First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer

Abstract Background Cytokine induced memory-like natural killer (CIML NK) cells combined with an IL-15 super-agonist (N-803) are a novel modality to treat relapsed/refractory head and neck cancer. Methods We report data from a phase I trial of haploidentical CIML NK cells combined with N-803 with or...

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Main Authors: Roman M. Shapiro, Michal Sheffer, Matthew A. Booker, Michael Y. Tolstorukov, Grace C. Birch, Moshe Sade-Feldman, Jacy Fang, Shuqiang Li, Wesley Lu, Michela Ansuinelli, Remy Dulery, Mubin Tarannum, Joanna Baginska, Nishant Dwivedi, Ashish Kothari, Livius Penter, Yasmin Z. Abdulhamid, Isabel E. Kaplan, Dinh Khanhlinh, Ravindra Uppaluri, Robert A. Redd, Sarah Nikiforow, John Koreth, Jerome Ritz, Catherine J. Wu, Robert J. Soiffer, Glenn J. Hanna, Rizwan Romee
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Hematology & Oncology
Subjects:
Clinical trial
Head and neck cancer
NK cells
Interleukin-15
Ipilimumab
Online Access:https://doi.org/10.1186/s13045-025-01669-3
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