HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies
During the last decade, a new therapeutic revolution has involved the management of hepatocellular carcinoma (HCC). This is made possible thanks to the documented efficacy of immunotherapy for this disease. In addition, new evidence has demonstrated the role of the gut–liver axis and gut microbiota...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Onco |
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| Online Access: | https://www.mdpi.com/2673-7523/5/1/9 |
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| author | Carmelo Laface Eleonora Lauricella Girolamo Ranieri Francesca Ambrogio Felicia Maria Maselli Elena Parlagreco Giulia Bernardi Elena Fea Gianmauro Numico |
| author_facet | Carmelo Laface Eleonora Lauricella Girolamo Ranieri Francesca Ambrogio Felicia Maria Maselli Elena Parlagreco Giulia Bernardi Elena Fea Gianmauro Numico |
| author_sort | Carmelo Laface |
| collection | DOAJ |
| description | During the last decade, a new therapeutic revolution has involved the management of hepatocellular carcinoma (HCC). This is made possible thanks to the documented efficacy of immunotherapy for this disease. In addition, new evidence has demonstrated the role of the gut–liver axis and gut microbiota in host homeostasis, tumor development, and response to therapies. In particular, intestinal dysbiosis can alter the tumor microenvironment, leading to the activation of intracellular signaling pathways that promote carcinogenesis. The composition of gut microbiota proved to influence the immune checkpoint inhibitors (ICIs) efficacy and drug toxicities. Therefore, this review aims to deepen knowledge about the immunomodulatory role of gut microbiota and its possible employment as diagnostic and predictive biomarkers in diagnosis and response to HCC immunotherapy, respectively. The research was conducted through the analysis of Pubmed and Web of Science (WoS) databases for literature studies on the relationship between gut microbiota and HCC from 2015 to 2025. |
| format | Article |
| id | doaj-art-2513ea6385b341f7b14fdfdaa217026d |
| institution | DOAJ |
| issn | 2673-7523 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Onco |
| spelling | doaj-art-2513ea6385b341f7b14fdfdaa217026d2025-08-20T02:42:24ZengMDPI AGOnco2673-75232025-02-0151910.3390/onco5010009HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic StrategiesCarmelo Laface0Eleonora Lauricella1Girolamo Ranieri2Francesca Ambrogio3Felicia Maria Maselli4Elena Parlagreco5Giulia Bernardi6Elena Fea7Gianmauro Numico8Medical Oncology, AOS. Croce e Carle, 12100 Cuneo, ItalyDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, ItalyUnità di Oncologia Interventistica, IRCCS Istituto Tumori Giovanni Paolo II Bari, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, ItalyUnit of Medical Oncology and Biomolecular Therapy, Department of Medical and Surgical Sciences, University of Foggia, Policlinico Riuniti, 71100 Foggia, ItalyMedical Oncology, AOS. Croce e Carle, 12100 Cuneo, ItalyMedical Oncology, AOS. Croce e Carle, 12100 Cuneo, ItalyMedical Oncology, AOS. Croce e Carle, 12100 Cuneo, ItalyMedical Oncology, AOS. Croce e Carle, 12100 Cuneo, ItalyDuring the last decade, a new therapeutic revolution has involved the management of hepatocellular carcinoma (HCC). This is made possible thanks to the documented efficacy of immunotherapy for this disease. In addition, new evidence has demonstrated the role of the gut–liver axis and gut microbiota in host homeostasis, tumor development, and response to therapies. In particular, intestinal dysbiosis can alter the tumor microenvironment, leading to the activation of intracellular signaling pathways that promote carcinogenesis. The composition of gut microbiota proved to influence the immune checkpoint inhibitors (ICIs) efficacy and drug toxicities. Therefore, this review aims to deepen knowledge about the immunomodulatory role of gut microbiota and its possible employment as diagnostic and predictive biomarkers in diagnosis and response to HCC immunotherapy, respectively. The research was conducted through the analysis of Pubmed and Web of Science (WoS) databases for literature studies on the relationship between gut microbiota and HCC from 2015 to 2025.https://www.mdpi.com/2673-7523/5/1/9HCCimmunotherapyimmune checkpoints inhibitors (ICIs)gut microbiota |
| spellingShingle | Carmelo Laface Eleonora Lauricella Girolamo Ranieri Francesca Ambrogio Felicia Maria Maselli Elena Parlagreco Giulia Bernardi Elena Fea Gianmauro Numico HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies Onco HCC immunotherapy immune checkpoints inhibitors (ICIs) gut microbiota |
| title | HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies |
| title_full | HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies |
| title_fullStr | HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies |
| title_full_unstemmed | HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies |
| title_short | HCC and Immunotherapy: The Potential Predictive Role of Gut Microbiota and Future Therapeutic Strategies |
| title_sort | hcc and immunotherapy the potential predictive role of gut microbiota and future therapeutic strategies |
| topic | HCC immunotherapy immune checkpoints inhibitors (ICIs) gut microbiota |
| url | https://www.mdpi.com/2673-7523/5/1/9 |
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