Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions
Summary: The circadian clock, a fundamental cellular mechanism, regulates the rhythmic expression of numerous genes and biological processes across various organs. Disruptions in this system, driven by genetic or environmental factors, have been reported to be involved in cancer progression. This re...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396424004870 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846161590625239040 |
|---|---|
| author | Marjan Motiei Raed Abu-Dawud Angela Relógio Chalid Assaf |
| author_facet | Marjan Motiei Raed Abu-Dawud Angela Relógio Chalid Assaf |
| author_sort | Marjan Motiei |
| collection | DOAJ |
| description | Summary: The circadian clock, a fundamental cellular mechanism, regulates the rhythmic expression of numerous genes and biological processes across various organs. Disruptions in this system, driven by genetic or environmental factors, have been reported to be involved in cancer progression. This review explores the role of the circadian clock in cancer hallmarks and its impact on cellular homeostasis within haematological malignancies. Drawing on findings from in vitro, in vivo, and clinical trials, this review highlights the potential of clock genes as diagnostic and prognostic biomarkers, and as therapeutic targets for optimising treatment timing. It discusses how circadian rhythms can enhance treatment efficacy through both pharmacological and non-pharmacological interventions, outlining strategies for optimising dosing schedules and implementing personalised chronobiological interventions, with a particular focus on haematological malignancies, including cutaneous lymphoma. Ongoing research holds promise for advancing personalised therapeutic approaches and ultimately improving cancer care standards. |
| format | Article |
| id | doaj-art-250b6ee6d621477d8c8e4818e1ecf8e5 |
| institution | Kabale University |
| issn | 2352-3964 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-250b6ee6d621477d8c8e4818e1ecf8e52024-11-21T06:04:09ZengElsevierEBioMedicine2352-39642024-12-01110105451Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventionsMarjan Motiei0Raed Abu-Dawud1Angela Relógio2Chalid Assaf3Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg 20457, GermanyInstitute for Molecular Medicine, MSH Medical School Hamburg, Hamburg 20457, GermanyInstitute for Systems Medicine, and Faculty of Human Medicine, MSH Medical School Hamburg, Hamburg 20457, GermanyInstitute for Molecular Medicine, MSH Medical School Hamburg, Hamburg 20457, Germany; Department of Dermatology, HELIOS Klinikum Krefeld, Krefeld 47805, Germany; Corresponding author. Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg 20457, Germany.Summary: The circadian clock, a fundamental cellular mechanism, regulates the rhythmic expression of numerous genes and biological processes across various organs. Disruptions in this system, driven by genetic or environmental factors, have been reported to be involved in cancer progression. This review explores the role of the circadian clock in cancer hallmarks and its impact on cellular homeostasis within haematological malignancies. Drawing on findings from in vitro, in vivo, and clinical trials, this review highlights the potential of clock genes as diagnostic and prognostic biomarkers, and as therapeutic targets for optimising treatment timing. It discusses how circadian rhythms can enhance treatment efficacy through both pharmacological and non-pharmacological interventions, outlining strategies for optimising dosing schedules and implementing personalised chronobiological interventions, with a particular focus on haematological malignancies, including cutaneous lymphoma. Ongoing research holds promise for advancing personalised therapeutic approaches and ultimately improving cancer care standards.http://www.sciencedirect.com/science/article/pii/S2352396424004870Circadian rhythmsNon-Hodgkin lymphomaCutaneous lymphomaCTCLLeukaemiaTherapeutic strategies |
| spellingShingle | Marjan Motiei Raed Abu-Dawud Angela Relógio Chalid Assaf Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions EBioMedicine Circadian rhythms Non-Hodgkin lymphoma Cutaneous lymphoma CTCL Leukaemia Therapeutic strategies |
| title | Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions |
| title_full | Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions |
| title_fullStr | Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions |
| title_full_unstemmed | Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions |
| title_short | Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions |
| title_sort | circadian rhythms in haematological malignancies therapeutic potential and personalised interventions |
| topic | Circadian rhythms Non-Hodgkin lymphoma Cutaneous lymphoma CTCL Leukaemia Therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2352396424004870 |
| work_keys_str_mv | AT marjanmotiei circadianrhythmsinhaematologicalmalignanciestherapeuticpotentialandpersonalisedinterventions AT raedabudawud circadianrhythmsinhaematologicalmalignanciestherapeuticpotentialandpersonalisedinterventions AT angelarelogio circadianrhythmsinhaematologicalmalignanciestherapeuticpotentialandpersonalisedinterventions AT chalidassaf circadianrhythmsinhaematologicalmalignanciestherapeuticpotentialandpersonalisedinterventions |