ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma

ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma

Abstract Adenosine 5′-diphosphate ribosylation factor–like 8B (ARL8B), a small GTPase, is involved in lysosome motility. Our study investigates the role of ARL8B in hepatocellular carcinoma (HCC) using in vitro and in vivo experiments, bioinformatics, and clinical data. We found that ARL8B expressio...

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Bibliographic Details
Main Authors: Liyan Wu, Zelin Weng, Xia Yang, Yuhua Huang, Yansong Lin, Shuo Li, Lingyi Fu, Jingping Yun
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Hepatocellular carcinoma
ARL8B
Lysosome
Immunotherapy
Tumor microenvironment
Cellular ecosystem
Online Access:https://doi.org/10.1038/s41598-025-97616-w
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https://doi.org/10.1038/s41598-025-97616-w

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