Synthesis of 2-Amino-4, 5-Diarylthiazole Derivatives and Evaluation of Their Anti-<i>Candida</i> Albicans Activity

Synthesis of 2-Amino-4, 5-Diarylthiazole Derivatives and Evaluation of Their Anti-<i>Candida</i> Albicans Activity

The thiazole heterocycle is one of the most common moieties found in various drugs. Using 2-aminothiazole as the core structure, the amino group was functionalized with an amide. As a result, 30 trisubstituted 2-amino-4, 5-diarylthiazole derivatives were synthesized, with different substitutions int...

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Bibliographic Details
Main Authors: Dongmei Gao, Lele Shi, Yuhang Huang, Yingmei Lv, Xuan Yang, Zhenting Du
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
2-Amino-4, 5-diarylthiazole
anti-<i>Candida albicans</i> activity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/30/7/1643
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