Pancreatic cancer subtyping - the keystone of precision treatment
In recent years, the incidence and mortality rates of pancreatic cancer have been rising, posing a severe threat to human health. Tumor heterogeneity remains a critical barrier to advancing diagnosis and treatment efforts. The lack of specific early symptoms, limited early diagnostic methods, high b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563725/full |
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| _version_ | 1850186560036667392 |
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| author | Zeyang Fan Yao Xiao Yan Du Yan Zhang Wence Zhou |
| author_facet | Zeyang Fan Yao Xiao Yan Du Yan Zhang Wence Zhou |
| author_sort | Zeyang Fan |
| collection | DOAJ |
| description | In recent years, the incidence and mortality rates of pancreatic cancer have been rising, posing a severe threat to human health. Tumor heterogeneity remains a critical barrier to advancing diagnosis and treatment efforts. The lack of specific early symptoms, limited early diagnostic methods, high biological complexity, and restricted therapeutic options contribute to the poor outcomes and prognosis of pancreatic cancer. Therefore, there is an urgent need to explore the different subtypes in-depth and develop personalized therapeutic strategies tailored to each subtype. Increasing evidence highlights the pivotal role of molecular subtyping in treating pancreatic cancer. This review focuses on recent advancements in classifying molecular subtypes and therapeutic approaches, discussed from the perspectives of gene mutations, genomics, transcriptomics, proteomics, metabolomics, and immunomics. |
| format | Article |
| id | doaj-art-24ffb56c3ab247f59f19c3498ecedf2d |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-24ffb56c3ab247f59f19c3498ecedf2d2025-08-20T02:16:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15637251563725Pancreatic cancer subtyping - the keystone of precision treatmentZeyang Fan0Yao Xiao1Yan Du2Yan Zhang3Wence Zhou4The Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery , The Second Hospital of Lanzhou University & The Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaIn recent years, the incidence and mortality rates of pancreatic cancer have been rising, posing a severe threat to human health. Tumor heterogeneity remains a critical barrier to advancing diagnosis and treatment efforts. The lack of specific early symptoms, limited early diagnostic methods, high biological complexity, and restricted therapeutic options contribute to the poor outcomes and prognosis of pancreatic cancer. Therefore, there is an urgent need to explore the different subtypes in-depth and develop personalized therapeutic strategies tailored to each subtype. Increasing evidence highlights the pivotal role of molecular subtyping in treating pancreatic cancer. This review focuses on recent advancements in classifying molecular subtypes and therapeutic approaches, discussed from the perspectives of gene mutations, genomics, transcriptomics, proteomics, metabolomics, and immunomics.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563725/fullpancreatic cancersubtypesgenomicstranscriptomicsproteomicsmetabolomics |
| spellingShingle | Zeyang Fan Yao Xiao Yan Du Yan Zhang Wence Zhou Pancreatic cancer subtyping - the keystone of precision treatment Frontiers in Immunology pancreatic cancer subtypes genomics transcriptomics proteomics metabolomics |
| title | Pancreatic cancer subtyping - the keystone of precision treatment |
| title_full | Pancreatic cancer subtyping - the keystone of precision treatment |
| title_fullStr | Pancreatic cancer subtyping - the keystone of precision treatment |
| title_full_unstemmed | Pancreatic cancer subtyping - the keystone of precision treatment |
| title_short | Pancreatic cancer subtyping - the keystone of precision treatment |
| title_sort | pancreatic cancer subtyping the keystone of precision treatment |
| topic | pancreatic cancer subtypes genomics transcriptomics proteomics metabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563725/full |
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