Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis
Abstract Background Hashimoto’s thyroiditis (HT) is associated with high cardiovascular risk. Thyroid volume has a notable dispersion of values in these patients. This study aims to clarify the association between thyroid antibodies, thyroid morphology, insulin resistance, and lipid profile in patie...
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| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01765-4 |
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| author | Bruna Couto Celestino Neves João Sérgio Neves Luís Delgado |
| author_facet | Bruna Couto Celestino Neves João Sérgio Neves Luís Delgado |
| author_sort | Bruna Couto |
| collection | DOAJ |
| description | Abstract Background Hashimoto’s thyroiditis (HT) is associated with high cardiovascular risk. Thyroid volume has a notable dispersion of values in these patients. This study aims to clarify the association between thyroid antibodies, thyroid morphology, insulin resistance, and lipid profile in patients with HT. Methods Cross-sectional study that includes 409 subjects diagnosed with HT. We assessed thyroid function, markers of autoimmunity, and markers of cardiovascular risk. We also evaluated thyroid ultrasound and studied the correlation between all factors. Results Among the study population, 9.8% were male, the mean age was 56.4 ± 17.4 years, 63.7% had dyslipidemia, and 29.5% had diabetes. Patients with hypothyroidism had higher levels of anti-thyroperoxidase antibodies (TPOab), and the decreased thyroid dimensions subgroup had a higher percentage of patients taking levothyroxine (98.7%). Positive correlations were found between TPOab and volume, and negative correlations were observed between thyroid-stimulating hormone (TSH) and volume. Conclusion The current study reveals a complex interrelationship between cardiovascular disease risk factors, thyroid function, autoimmunity, and thyroid volume in HT. These associations may be of clinical relevance, and further studies are needed to elucidate how these findings may be used clinically to reduce the cardiovascular risk in patients with HT. |
| format | Article |
| id | doaj-art-24fe3785f79b41b89732874ec2f15496 |
| institution | OA Journals |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-24fe3785f79b41b89732874ec2f154962025-08-20T01:48:05ZengBMCBMC Endocrine Disorders1472-68232024-12-012411810.1186/s12902-024-01765-4Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditisBruna Couto0Celestino Neves1João Sérgio Neves2Luís Delgado3Faculty of Medicine, University of PortoFaculty of Medicine, University of PortoDepartment of Endocrinology, Diabetes and Metabolism, ULS São JoãoBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of PortoAbstract Background Hashimoto’s thyroiditis (HT) is associated with high cardiovascular risk. Thyroid volume has a notable dispersion of values in these patients. This study aims to clarify the association between thyroid antibodies, thyroid morphology, insulin resistance, and lipid profile in patients with HT. Methods Cross-sectional study that includes 409 subjects diagnosed with HT. We assessed thyroid function, markers of autoimmunity, and markers of cardiovascular risk. We also evaluated thyroid ultrasound and studied the correlation between all factors. Results Among the study population, 9.8% were male, the mean age was 56.4 ± 17.4 years, 63.7% had dyslipidemia, and 29.5% had diabetes. Patients with hypothyroidism had higher levels of anti-thyroperoxidase antibodies (TPOab), and the decreased thyroid dimensions subgroup had a higher percentage of patients taking levothyroxine (98.7%). Positive correlations were found between TPOab and volume, and negative correlations were observed between thyroid-stimulating hormone (TSH) and volume. Conclusion The current study reveals a complex interrelationship between cardiovascular disease risk factors, thyroid function, autoimmunity, and thyroid volume in HT. These associations may be of clinical relevance, and further studies are needed to elucidate how these findings may be used clinically to reduce the cardiovascular risk in patients with HT.https://doi.org/10.1186/s12902-024-01765-4ThyroiditisAutoimmuneHashimoto diseaseHeart disease risk factorsAutoimmunity |
| spellingShingle | Bruna Couto Celestino Neves João Sérgio Neves Luís Delgado Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis BMC Endocrine Disorders Thyroiditis Autoimmune Hashimoto disease Heart disease risk factors Autoimmunity |
| title | Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis |
| title_full | Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis |
| title_fullStr | Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis |
| title_full_unstemmed | Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis |
| title_short | Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis |
| title_sort | thyroid function autoimmunity thyroid volume and metabolic profile in people with hashimoto thyroiditis |
| topic | Thyroiditis Autoimmune Hashimoto disease Heart disease risk factors Autoimmunity |
| url | https://doi.org/10.1186/s12902-024-01765-4 |
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