Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.

Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.

Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the molecular regulators involved in the differentiati...

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Main Authors: Guihua Wang, Dan Zhang, Zhifeng He, Bin Mao, Xiao Hu, Li Chen, Qingxin Yang, Zhen Zhou, Yating Zhang, Kepan Linghu, Chao Tang, Zijie Xu, Defu Liu, Junwei Song, Huiying Wang, Yishan Lin, Ruihan Li, Jing-Wen Lin, Lu Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012877
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