Circulating mitochondrial biomarkers in acute coronary syndrome
BackgroundAcute coronary syndrome (ACS) is the leading cause of mortality in developed countries. Mitochondrial dysfunction is a hallmark of various cardiometabolic diseases, including ACS. Emerging evidence suggests that evaluating mitochondrial biomarkers in plasma may offer valuable insights into...
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2025-05-01
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| author | Andrea Iboleon-Jimenez María J. Sánchez-Quintero María J. Sánchez-Quintero María J. Sánchez-Quintero Ada D. M. Carmona-Segovia Ada D. M. Carmona-Segovia Ada D. M. Carmona-Segovia Bélen Sojo Bélen Sojo Ana María Fernández-Ramos Ana María Fernández-Ramos Luis García-Rodríguez Luis García-Rodríguez Ana I. Molina-Ramos Ana I. Molina-Ramos Ana I. Molina-Ramos José Manuel García-Pinilla José Manuel García-Pinilla José Manuel García-Pinilla José Manuel García-Pinilla Manuel Jimenez-Navarro Manuel Jimenez-Navarro Manuel Jimenez-Navarro Manuel Jimenez-Navarro Almudena Ortega-Gomez Almudena Ortega-Gomez Almudena Ortega-Gomez |
| author_facet | Andrea Iboleon-Jimenez María J. Sánchez-Quintero María J. Sánchez-Quintero María J. Sánchez-Quintero Ada D. M. Carmona-Segovia Ada D. M. Carmona-Segovia Ada D. M. Carmona-Segovia Bélen Sojo Bélen Sojo Ana María Fernández-Ramos Ana María Fernández-Ramos Luis García-Rodríguez Luis García-Rodríguez Ana I. Molina-Ramos Ana I. Molina-Ramos Ana I. Molina-Ramos José Manuel García-Pinilla José Manuel García-Pinilla José Manuel García-Pinilla José Manuel García-Pinilla Manuel Jimenez-Navarro Manuel Jimenez-Navarro Manuel Jimenez-Navarro Manuel Jimenez-Navarro Almudena Ortega-Gomez Almudena Ortega-Gomez Almudena Ortega-Gomez |
| author_sort | Andrea Iboleon-Jimenez |
| collection | DOAJ |
| description | BackgroundAcute coronary syndrome (ACS) is the leading cause of mortality in developed countries. Mitochondrial dysfunction is a hallmark of various cardiometabolic diseases, including ACS. Emerging evidence suggests that evaluating mitochondrial biomarkers in plasma may offer valuable insights into the pathophysiology and management of these conditions. The present study aims to analyse the effect of ACS, sex and their interaction on plasma levels of mitochondrial markers, such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) and citrate syntetase (CS).MethodsA total of 18 ACS patients (8 women and 10 men) and 20 controls (8 women and 12 men) were included in this study. Venous blood samples were collected from participants after a 12-h overnight fast. Plasma levels of mitochondrial PGC-1α, MOTS-c and CS were measured.ResultsACS significantly reduced plasma levels of PGC-1α and MOTS-c. Sex did not shown a significant effect on these markers. Additionally, MOTS-c positively correlated with the first troponin and hemoglobin, PGC-1α negatively correlated with glucose and positively with HDL-cholesterol, and CS showed negative correlations with NT-proBNP, C-reactive protein, and hemoglobin.ConclusionMitochondria markers, MOTS-c and PGC-1α, are altered in ACS patients, with no observed sex differences. These findings represent an initial step toward integrating personalized medicine into the clinical management of ACS. Nonetheless, further studies are required to fully elucidate the role of these markers in this pathology. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-24f863eb696b4907b4e90ce4d86514762025-08-20T03:49:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.15683051568305Circulating mitochondrial biomarkers in acute coronary syndromeAndrea Iboleon-Jimenez0María J. Sánchez-Quintero1María J. Sánchez-Quintero2María J. Sánchez-Quintero3Ada D. M. Carmona-Segovia4Ada D. M. Carmona-Segovia5Ada D. M. Carmona-Segovia6Bélen Sojo7Bélen Sojo8Ana María Fernández-Ramos9Ana María Fernández-Ramos10Luis García-Rodríguez11Luis García-Rodríguez12Ana I. Molina-Ramos13Ana I. Molina-Ramos14Ana I. Molina-Ramos15José Manuel García-Pinilla16José Manuel García-Pinilla17José Manuel García-Pinilla18José Manuel García-Pinilla19Manuel Jimenez-Navarro20Manuel Jimenez-Navarro21Manuel Jimenez-Navarro22Manuel Jimenez-Navarro23Almudena Ortega-Gomez24Almudena Ortega-Gomez25Almudena Ortega-Gomez26Unidad Docente Multiprofesional de Atención Familiar y Comunitaria, Distrito de Atención Primaria Málaga-Guadalhorce; Faculty of Medicine, University of Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainDepartment of Cardiology and Cardiovascular Surgery, Virgen de la Victoria University Hospital, Málaga, SpainCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainDepartment of Cardiology and Cardiovascular Surgery, Virgen de la Victoria University Hospital, Málaga, SpainCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainEndocrinology and Nutrition UGC, Victoria Virgen University Hospital, Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainClinical Analysis UGC, Hospital Universitario Virgen de la Victoria, Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainDepartment of Cardiology and Cardiovascular Surgery, Virgen de la Victoria University Hospital, Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainDepartment of Cardiology and Cardiovascular Surgery, Virgen de la Victoria University Hospital, Málaga, SpainCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainDepartment of Cardiology and Cardiovascular Surgery, Virgen de la Victoria University Hospital, Málaga, SpainCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, SpainDepartment of Dermatology and Medicine, Faculty of Medicine, University of Malaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainDepartment of Cardiology and Cardiovascular Surgery, Virgen de la Victoria University Hospital, Málaga, SpainCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, SpainDepartment of Dermatology and Medicine, Faculty of Medicine, University of Malaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, SpainEndocrinology and Nutrition UGC, Victoria Virgen University Hospital, Málaga, SpainCentro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainBackgroundAcute coronary syndrome (ACS) is the leading cause of mortality in developed countries. Mitochondrial dysfunction is a hallmark of various cardiometabolic diseases, including ACS. Emerging evidence suggests that evaluating mitochondrial biomarkers in plasma may offer valuable insights into the pathophysiology and management of these conditions. The present study aims to analyse the effect of ACS, sex and their interaction on plasma levels of mitochondrial markers, such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) and citrate syntetase (CS).MethodsA total of 18 ACS patients (8 women and 10 men) and 20 controls (8 women and 12 men) were included in this study. Venous blood samples were collected from participants after a 12-h overnight fast. Plasma levels of mitochondrial PGC-1α, MOTS-c and CS were measured.ResultsACS significantly reduced plasma levels of PGC-1α and MOTS-c. Sex did not shown a significant effect on these markers. Additionally, MOTS-c positively correlated with the first troponin and hemoglobin, PGC-1α negatively correlated with glucose and positively with HDL-cholesterol, and CS showed negative correlations with NT-proBNP, C-reactive protein, and hemoglobin.ConclusionMitochondria markers, MOTS-c and PGC-1α, are altered in ACS patients, with no observed sex differences. These findings represent an initial step toward integrating personalized medicine into the clinical management of ACS. Nonetheless, further studies are required to fully elucidate the role of these markers in this pathology.https://www.frontiersin.org/articles/10.3389/fmed.2025.1568305/fullacute coronary syndromecardiovascular diseasesmitochondrial biomarkerssexsex dimorphism |
| spellingShingle | Andrea Iboleon-Jimenez María J. Sánchez-Quintero María J. Sánchez-Quintero María J. Sánchez-Quintero Ada D. M. Carmona-Segovia Ada D. M. Carmona-Segovia Ada D. M. Carmona-Segovia Bélen Sojo Bélen Sojo Ana María Fernández-Ramos Ana María Fernández-Ramos Luis García-Rodríguez Luis García-Rodríguez Ana I. Molina-Ramos Ana I. Molina-Ramos Ana I. Molina-Ramos José Manuel García-Pinilla José Manuel García-Pinilla José Manuel García-Pinilla José Manuel García-Pinilla Manuel Jimenez-Navarro Manuel Jimenez-Navarro Manuel Jimenez-Navarro Manuel Jimenez-Navarro Almudena Ortega-Gomez Almudena Ortega-Gomez Almudena Ortega-Gomez Circulating mitochondrial biomarkers in acute coronary syndrome Frontiers in Medicine acute coronary syndrome cardiovascular diseases mitochondrial biomarkers sex sex dimorphism |
| title | Circulating mitochondrial biomarkers in acute coronary syndrome |
| title_full | Circulating mitochondrial biomarkers in acute coronary syndrome |
| title_fullStr | Circulating mitochondrial biomarkers in acute coronary syndrome |
| title_full_unstemmed | Circulating mitochondrial biomarkers in acute coronary syndrome |
| title_short | Circulating mitochondrial biomarkers in acute coronary syndrome |
| title_sort | circulating mitochondrial biomarkers in acute coronary syndrome |
| topic | acute coronary syndrome cardiovascular diseases mitochondrial biomarkers sex sex dimorphism |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1568305/full |
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