Hypertension increases PPV for polycystic kidney disease in PKD1 and PKD2 variant carriers

Hypertension increases PPV for polycystic kidney disease in PKD1 and PKD2 variant carriers

Summary: Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic form of KD. Although rare causal variants in the PKD1 and PKD2 genes have been identified, their penetrance and the disease progression and outcome are known to vary, and treatment efficacy in these carriers lags co...

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Bibliographic Details
Main Authors: Natalie Telis, Lisa McEwen, Alexandre Bolze, Joshua H. Lipschutz, Leon W. Sweer, Daniel P. Judge, Pamala A. Pawloski, Joseph J. Grzymski, Catherine Hajek, Kelly M. Schiabor Barrett, Nicole L. Washington, Elizabeth T. Cirulli
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:HGG Advances
Subjects:
genetics
genomics
genetic testing
polycystic kidney disease
population screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247725000478
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