Simultaneous Quantification of Methotrexate and Its Metabolite 7-Hydroxy-Methotrexate in Human Plasma for Therapeutic Drug Monitoring

Simultaneous Quantification of Methotrexate and Its Metabolite 7-Hydroxy-Methotrexate in Human Plasma for Therapeutic Drug Monitoring

Objective. To establish and validate a simple, sensitive, and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of methotrexate (MTX) and its major metabolite 7-hydroxy-methotrexate (7-OH-MTX) in human plasma. Method. The chromatographic separation was achi...

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Main Authors: Xinxin Ren, Zhipeng Wang, Yunlei Yun, Guangyi Meng, Xialan Zhang, Huamin Ding, Ying Xu, Hansheng Bai, Jing Liu, Xia Li, Shouhong Gao, Lifeng Huang, Wansheng Chen
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:International Journal of Analytical Chemistry
Online Access:http://dx.doi.org/10.1155/2019/1536532
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