Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus
Aim: Natural products possess diverse pharmacological properties that are effective and safe for treating and managing amnesia; however, there is little or no scientific proof for most of their claims. This study evaluates the efficacy of Lecaniodiscus cupanioide-supplemented diets (LCSD) and Alchor...
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Open Exploration Publishing Inc.
2025-05-01
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| Series: | Exploration of Neuroscience |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100690/100690.pdf |
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| author | Odunayo Michael Agunloye Ayodele Ebenezer Aijo Olamide Wilson Fasakin Ganiyu Oboh |
| author_facet | Odunayo Michael Agunloye Ayodele Ebenezer Aijo Olamide Wilson Fasakin Ganiyu Oboh |
| author_sort | Odunayo Michael Agunloye |
| collection | DOAJ |
| description | Aim: Natural products possess diverse pharmacological properties that are effective and safe for treating and managing amnesia; however, there is little or no scientific proof for most of their claims. This study evaluates the efficacy of Lecaniodiscus cupanioide-supplemented diets (LCSD) and Alchornea cordifolia-supplemented diets (ACSD) on scopolamine-induced amnesia in male rats. Roots of L. cupanioide and A. cordifolia were obtained and used to formulate 10% and 20% supplemented diets. Methods: Experimental animals were orally pre-fed LCSD and ACSD for 14 days before the induction of amnesia via single i.p. (intraperitoneal) administration of scopolamine (2 mg/kg body weight). Experimental animals were subjected to a Y-maze test to evaluate cognitive performance before experiment termination. The activities of hippocampal key enzymes linked to cognitive function were determined. Results: The result of the Y-maze showed that the induction of amnesia significantly (p < 0.001) reduced spatial memory function, which was protected against LCSD and ACSD pre-treated rats. Also, pre-treatment with supplemented diets inhibited the significant (p < 0.01) aggravation of monoamine oxidase, arginase, tumor necrosis factor-α, malonaldehyde, myeloperoxidase, acetylcholinesterase, and butyrylcholinesterase concentrations, and the significant (p < 0.05) depletion of dopamine, nitric oxide, interleukin-6, total thiol, and non-protein thiol concentrations, in comparison with that observed with amnesic-induced untreated rats. Comparatively, LCSD was more effective in preventing neuronal enzymatic imbalances, while ACSD was more effective in avoiding antioxidant status depletion. Conclusions: Conclusively, this study established that the supplemented diets possess potent anti-amnesic and neuroprotective abilities. Furthermore, this study recommends supplemented diets as a dietary intervention for preventing and managing amnesic conditions. |
| format | Article |
| id | doaj-art-24ef1ea5f9ec425a8c548d76eaeabd80 |
| institution | DOAJ |
| issn | 2834-5347 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Neuroscience |
| spelling | doaj-art-24ef1ea5f9ec425a8c548d76eaeabd802025-08-20T03:08:47ZengOpen Exploration Publishing Inc.Exploration of Neuroscience2834-53472025-05-01410069010.37349/en.2025.100690Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampusOdunayo Michael Agunloye0https://orcid.org/0000-0002-8835-0472Ayodele Ebenezer Aijo1Olamide Wilson Fasakin2https://orcid.org/0000-0002-1352-3252Ganiyu Oboh3https://orcid.org/0000-0001-5167-9779Department of Biochemistry, School of Life Sciences, Federal University of Technology, Akure 340001, NigeriaDepartment of Biochemistry, School of Life Sciences, Federal University of Technology, Akure 340001, NigeriaDepartment of Biochemistry, School of Life Sciences, Federal University of Technology, Akure 340001, Nigeria; Department of Biomedical Technology, School of Basic Medical Sciences, Federal University of Technology, Akure 340001, NigeriaDepartment of Biochemistry, School of Life Sciences, Federal University of Technology, Akure 340001, NigeriaAim: Natural products possess diverse pharmacological properties that are effective and safe for treating and managing amnesia; however, there is little or no scientific proof for most of their claims. This study evaluates the efficacy of Lecaniodiscus cupanioide-supplemented diets (LCSD) and Alchornea cordifolia-supplemented diets (ACSD) on scopolamine-induced amnesia in male rats. Roots of L. cupanioide and A. cordifolia were obtained and used to formulate 10% and 20% supplemented diets. Methods: Experimental animals were orally pre-fed LCSD and ACSD for 14 days before the induction of amnesia via single i.p. (intraperitoneal) administration of scopolamine (2 mg/kg body weight). Experimental animals were subjected to a Y-maze test to evaluate cognitive performance before experiment termination. The activities of hippocampal key enzymes linked to cognitive function were determined. Results: The result of the Y-maze showed that the induction of amnesia significantly (p < 0.001) reduced spatial memory function, which was protected against LCSD and ACSD pre-treated rats. Also, pre-treatment with supplemented diets inhibited the significant (p < 0.01) aggravation of monoamine oxidase, arginase, tumor necrosis factor-α, malonaldehyde, myeloperoxidase, acetylcholinesterase, and butyrylcholinesterase concentrations, and the significant (p < 0.05) depletion of dopamine, nitric oxide, interleukin-6, total thiol, and non-protein thiol concentrations, in comparison with that observed with amnesic-induced untreated rats. Comparatively, LCSD was more effective in preventing neuronal enzymatic imbalances, while ACSD was more effective in avoiding antioxidant status depletion. Conclusions: Conclusively, this study established that the supplemented diets possess potent anti-amnesic and neuroprotective abilities. Furthermore, this study recommends supplemented diets as a dietary intervention for preventing and managing amnesic conditions.https://www.explorationpub.com/uploads/Article/A100690/100690.pdflecaniodiscus cupanioidealchornea cordifoliacholinergicmonoaminergicinflammatory |
| spellingShingle | Odunayo Michael Agunloye Ayodele Ebenezer Aijo Olamide Wilson Fasakin Ganiyu Oboh Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus Exploration of Neuroscience lecaniodiscus cupanioide alchornea cordifolia cholinergic monoaminergic inflammatory |
| title | Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus |
| title_full | Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus |
| title_fullStr | Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus |
| title_full_unstemmed | Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus |
| title_short | Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus |
| title_sort | efficacy of lecaniodiscus cupanioide and alchornea cordifolia supplemented diets on neurotransmitter neuroinflammatory and antioxidant systems of scopolamine induced amnesia in rat hippocampus |
| topic | lecaniodiscus cupanioide alchornea cordifolia cholinergic monoaminergic inflammatory |
| url | https://www.explorationpub.com/uploads/Article/A100690/100690.pdf |
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