Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors
Enhancing cognitive functions through noninvasive brain stimulation is of enormous public interest, particularly for the aging population in whom processes such as working memory are known to decline. In a randomized double-blind crossover study, we investigated the acute behavioral and neural after...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6664479 |
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| author | P. Šimko M. Pupíková M. Gajdoš I. Rektorová |
| author_facet | P. Šimko M. Pupíková M. Gajdoš I. Rektorová |
| author_sort | P. Šimko |
| collection | DOAJ |
| description | Enhancing cognitive functions through noninvasive brain stimulation is of enormous public interest, particularly for the aging population in whom processes such as working memory are known to decline. In a randomized double-blind crossover study, we investigated the acute behavioral and neural aftereffects of bifrontal and frontoparietal transcranial direct current stimulation (tDCS) combined with visual working memory (VWM) training on 25 highly educated older adults. Resting-state functional connectivity (rs-FC) analysis was performed prior to and after each stimulation session with a focus on the frontoparietal control network (FPCN). The bifrontal montage with anode over the left dorsolateral prefrontal cortex enhanced VWM accuracy as compared to the sham stimulation. With the rs-FC within the FPCN, we observed significant stimulation×time interaction using bifrontal tDCS. We found no cognitive aftereffects of the frontoparietal tDCS compared to sham stimulation. Our study shows that a single bifrontal tDCS combined with cognitive training may enhance VWM performance and rs-FC within the relevant brain network even in highly educated older adults. |
| format | Article |
| id | doaj-art-24ebf5ed0d4a4e319cd7c7b8e4c1561e |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-24ebf5ed0d4a4e319cd7c7b8e4c1561e2025-08-20T02:04:43ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66644796664479Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy SeniorsP. Šimko0M. Pupíková1M. Gajdoš2I. Rektorová3Central European Institute of Technology-CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech RepublicCentral European Institute of Technology-CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech RepublicCentral European Institute of Technology-CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech RepublicCentral European Institute of Technology-CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech RepublicEnhancing cognitive functions through noninvasive brain stimulation is of enormous public interest, particularly for the aging population in whom processes such as working memory are known to decline. In a randomized double-blind crossover study, we investigated the acute behavioral and neural aftereffects of bifrontal and frontoparietal transcranial direct current stimulation (tDCS) combined with visual working memory (VWM) training on 25 highly educated older adults. Resting-state functional connectivity (rs-FC) analysis was performed prior to and after each stimulation session with a focus on the frontoparietal control network (FPCN). The bifrontal montage with anode over the left dorsolateral prefrontal cortex enhanced VWM accuracy as compared to the sham stimulation. With the rs-FC within the FPCN, we observed significant stimulation×time interaction using bifrontal tDCS. We found no cognitive aftereffects of the frontoparietal tDCS compared to sham stimulation. Our study shows that a single bifrontal tDCS combined with cognitive training may enhance VWM performance and rs-FC within the relevant brain network even in highly educated older adults.http://dx.doi.org/10.1155/2021/6664479 |
| spellingShingle | P. Šimko M. Pupíková M. Gajdoš I. Rektorová Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors Neural Plasticity |
| title | Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors |
| title_full | Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors |
| title_fullStr | Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors |
| title_full_unstemmed | Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors |
| title_short | Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors |
| title_sort | cognitive aftereffects of acute tdcs coupled with cognitive training an fmri study in healthy seniors |
| url | http://dx.doi.org/10.1155/2021/6664479 |
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