Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis
Introduction: Jugular Foramen Schwannomas (JFS) have been traditionally treated with surgical resection with an associated significant post-operative morbidity. Stereotactic radiosurgery has been investigated as potentially minimally invasive alternative to microsurgery. The aim of this study was to...
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Elsevier
2025-01-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259013972400142X |
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| author | Timoleon Siempis Spyridon Voulgaris George A. Alexiou |
| author_facet | Timoleon Siempis Spyridon Voulgaris George A. Alexiou |
| author_sort | Timoleon Siempis |
| collection | DOAJ |
| description | Introduction: Jugular Foramen Schwannomas (JFS) have been traditionally treated with surgical resection with an associated significant post-operative morbidity. Stereotactic radiosurgery has been investigated as potentially minimally invasive alternative to microsurgery. The aim of this study was to provide a systematic review and meta-analysis of the available literature regarding the outcomes of cases of JFS treated with radiosurgery. Methods: A literature review until 28th of March 2023 was performed. All studies looking at the outcomes of radiosurgery for the treatment of JFS were included. Studies including non-vestibular schwannomas without clear distinction of the tumour type were excluded. Risk of bias was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) scale. Results: Eight (8) studies with a total of 375 patients met the inclusion and exclusion criteria and were included in the analysis. Pooled overall tumour control rate was 93.2 % (95 % CI 89.8–96.6) after a weighted mean follow-up of 54.07 months (95 % CI 46.8–61.3). Patient free survival was reported only in 4 studies and ranged from 87 % to 97 % and 76.9–93.8 % in 5 and 10 years respectively. The radiation induced cranial nerve deficits rates after GKRS were 3.6 % (95%CI 1.7, 5.5 %). Conclusion: According to our findings, radiosurgery for JFS has favourable clinical outcomes with a high rate of long-term tumour control and low complication rates. |
| format | Article |
| id | doaj-art-24e5e86f0204437d9a570f390fb1cee8 |
| institution | Kabale University |
| issn | 2590-1397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj-art-24e5e86f0204437d9a570f390fb1cee82025-02-10T04:34:49ZengElsevierWorld Neurosurgery: X2590-13972025-01-0125100411Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysisTimoleon Siempis0Spyridon Voulgaris1George A. Alexiou2Department of Neurosurgery, University of Ioannina, Ioannina, GreeceDepartment of Neurosurgery, University of Ioannina, Ioannina, GreeceCorresponding author.; Department of Neurosurgery, University of Ioannina, Ioannina, GreeceIntroduction: Jugular Foramen Schwannomas (JFS) have been traditionally treated with surgical resection with an associated significant post-operative morbidity. Stereotactic radiosurgery has been investigated as potentially minimally invasive alternative to microsurgery. The aim of this study was to provide a systematic review and meta-analysis of the available literature regarding the outcomes of cases of JFS treated with radiosurgery. Methods: A literature review until 28th of March 2023 was performed. All studies looking at the outcomes of radiosurgery for the treatment of JFS were included. Studies including non-vestibular schwannomas without clear distinction of the tumour type were excluded. Risk of bias was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) scale. Results: Eight (8) studies with a total of 375 patients met the inclusion and exclusion criteria and were included in the analysis. Pooled overall tumour control rate was 93.2 % (95 % CI 89.8–96.6) after a weighted mean follow-up of 54.07 months (95 % CI 46.8–61.3). Patient free survival was reported only in 4 studies and ranged from 87 % to 97 % and 76.9–93.8 % in 5 and 10 years respectively. The radiation induced cranial nerve deficits rates after GKRS were 3.6 % (95%CI 1.7, 5.5 %). Conclusion: According to our findings, radiosurgery for JFS has favourable clinical outcomes with a high rate of long-term tumour control and low complication rates.http://www.sciencedirect.com/science/article/pii/S259013972400142XJugular foramen schwannomasGamma knifeStereotactic radiosurgeryTumour controlFunctional outcome |
| spellingShingle | Timoleon Siempis Spyridon Voulgaris George A. Alexiou Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis World Neurosurgery: X Jugular foramen schwannomas Gamma knife Stereotactic radiosurgery Tumour control Functional outcome |
| title | Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis |
| title_full | Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis |
| title_fullStr | Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis |
| title_full_unstemmed | Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis |
| title_short | Gamma-knife radiosurgery for jugular foramen schwannomas. A systematic review and meta-analysis |
| title_sort | gamma knife radiosurgery for jugular foramen schwannomas a systematic review and meta analysis |
| topic | Jugular foramen schwannomas Gamma knife Stereotactic radiosurgery Tumour control Functional outcome |
| url | http://www.sciencedirect.com/science/article/pii/S259013972400142X |
| work_keys_str_mv | AT timoleonsiempis gammakniferadiosurgeryforjugularforamenschwannomasasystematicreviewandmetaanalysis AT spyridonvoulgaris gammakniferadiosurgeryforjugularforamenschwannomasasystematicreviewandmetaanalysis AT georgeaalexiou gammakniferadiosurgeryforjugularforamenschwannomasasystematicreviewandmetaanalysis |