Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function
Alcoholic liver disease (ALD) is one of the major global public health problems. Yeast extract (YE), a product prepared from yeast, has been proven to have antioxidant and anti-inflammatory properties. However, the potential role of YE in the prevention of ALD remains unclear. The present study aime...
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Tsinghua University Press
2025-06-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250146 |
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| author | Hao Han Lei Tian Yajing Dong Yanyang Han Xiaoman Wang Qian Cheng Haibo Zhang Yan Zhang |
| author_facet | Hao Han Lei Tian Yajing Dong Yanyang Han Xiaoman Wang Qian Cheng Haibo Zhang Yan Zhang |
| author_sort | Hao Han |
| collection | DOAJ |
| description | Alcoholic liver disease (ALD) is one of the major global public health problems. Yeast extract (YE), a product prepared from yeast, has been proven to have antioxidant and anti-inflammatory properties. However, the potential role of YE in the prevention of ALD remains unclear. The present study aimed to investigate the protective effects of YE on ALD and explore the underlying mechanism based on gut microbiota. The result showed that YE supplementation significantly ameliorated chronic alcohol exposure-induced liver injury in mice. In addition, YE counteracted alcohol-induced gut dysbiosis, intestinal barrier dysfunction, lipopolysaccharide (LPS) leakage-induced inflammatory response in the liver. Moreover, microbiota depletion by a broad-spectrum antibiotic was sufficient to block the protective effect of YE on ALD, indicating the contribution of gut dysbiosis modulation to the hepatoprotective role of YE. Furthermore, we demonstrated the causal relationship between gut microbiota and hepatoprotective effects of YE with the fecal microbiota transplantation (FMT) experiment. Compared with the ALD-FMT mice, gut dysbiosis, intestinal barrier dysfunction, LPS/TLR4 signaling pathway activation, and liver inflammatory response were significantly improved in the YE-FMT mice. Together, our findings highlight that dietary YE protects against ALD through gut dysbiosis correction. |
| format | Article |
| id | doaj-art-24e44cc2dc3e4f40965c0118a9c292fb |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-24e44cc2dc3e4f40965c0118a9c292fb2025-08-20T03:41:14ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-06-01146925014610.26599/FSHW.2024.9250146Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier functionHao Han0Lei Tian1Yajing Dong2Yanyang Han3Xiaoman Wang4Qian Cheng5Haibo Zhang6Yan Zhang7Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan 030001, ChinaHubei Provincial Key Laboratory of Yeast Function, Yichang 443003, ChinaHubei Provincial Key Laboratory of Yeast Function, Yichang 443003, ChinaHubei Provincial Key Laboratory of Yeast Function, Yichang 443003, ChinaAlcoholic liver disease (ALD) is one of the major global public health problems. Yeast extract (YE), a product prepared from yeast, has been proven to have antioxidant and anti-inflammatory properties. However, the potential role of YE in the prevention of ALD remains unclear. The present study aimed to investigate the protective effects of YE on ALD and explore the underlying mechanism based on gut microbiota. The result showed that YE supplementation significantly ameliorated chronic alcohol exposure-induced liver injury in mice. In addition, YE counteracted alcohol-induced gut dysbiosis, intestinal barrier dysfunction, lipopolysaccharide (LPS) leakage-induced inflammatory response in the liver. Moreover, microbiota depletion by a broad-spectrum antibiotic was sufficient to block the protective effect of YE on ALD, indicating the contribution of gut dysbiosis modulation to the hepatoprotective role of YE. Furthermore, we demonstrated the causal relationship between gut microbiota and hepatoprotective effects of YE with the fecal microbiota transplantation (FMT) experiment. Compared with the ALD-FMT mice, gut dysbiosis, intestinal barrier dysfunction, LPS/TLR4 signaling pathway activation, and liver inflammatory response were significantly improved in the YE-FMT mice. Together, our findings highlight that dietary YE protects against ALD through gut dysbiosis correction.https://www.sciopen.com/article/10.26599/FSHW.2024.9250146yeast extractalcoholic liver diseasegut microbiotalipopolysaccharideinflammatory response |
| spellingShingle | Hao Han Lei Tian Yajing Dong Yanyang Han Xiaoman Wang Qian Cheng Haibo Zhang Yan Zhang Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function Food Science and Human Wellness yeast extract alcoholic liver disease gut microbiota lipopolysaccharide inflammatory response |
| title | Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function |
| title_full | Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function |
| title_fullStr | Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function |
| title_full_unstemmed | Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function |
| title_short | Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function |
| title_sort | dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function |
| topic | yeast extract alcoholic liver disease gut microbiota lipopolysaccharide inflammatory response |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250146 |
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