IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production an...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/840315 |
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| author | Dominique M. A. Bullens Ann Decraene Sven Seys Lieven J. Dupont |
| author_facet | Dominique M. A. Bullens Ann Decraene Sven Seys Lieven J. Dupont |
| author_sort | Dominique M. A. Bullens |
| collection | DOAJ |
| description | Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases. |
| format | Article |
| id | doaj-art-24e0148cead441058f287b18734bc7ab |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-24e0148cead441058f287b18734bc7ab2025-08-20T03:54:52ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/840315840315IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical ImplicationsDominique M. A. Bullens0Ann Decraene1Sven Seys2Lieven J. Dupont3Pediatrics Division, University Hospitals Leuven, 3000 Leuven, BelgiumLaboratory of Pneumology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, BelgiumLaboratory of Pneumology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, BelgiumLaboratory of Pneumology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, BelgiumSince the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases.http://dx.doi.org/10.1155/2013/840315 |
| spellingShingle | Dominique M. A. Bullens Ann Decraene Sven Seys Lieven J. Dupont IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications Clinical and Developmental Immunology |
| title | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
| title_full | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
| title_fullStr | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
| title_full_unstemmed | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
| title_short | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
| title_sort | il 17a in human respiratory diseases innate or adaptive immunity clinical implications |
| url | http://dx.doi.org/10.1155/2013/840315 |
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