Advancing veterinary vaccines design through trained immunity insights
Trained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. This perspective examines how trained immunity can be integrated into veterinary vaccine design through metabolic reprogramming and epigen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1524668/full |
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| author | Xin Wang Xin Wang Xin Wang Xin Wang Guohua Yu Guohua Yu Guohua Yu |
| author_facet | Xin Wang Xin Wang Xin Wang Xin Wang Guohua Yu Guohua Yu Guohua Yu |
| author_sort | Xin Wang |
| collection | DOAJ |
| description | Trained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. This perspective examines how trained immunity can be integrated into veterinary vaccine design through metabolic reprogramming and epigenetic modifications. We analyze key molecular mechanisms, including the shift to aerobic glycolysis and sustained epigenetic changes, that enable enhanced immune responses. Strategic approaches for vaccine optimization are proposed, focusing on selecting effective trained immunity inducers, developing innovative adjuvant systems, and achieving synergistic enhancement of immune responses. While implementation challenges exist, including individual response variations and safety considerations, trained immunity-based vaccines show potential for providing broader protection against emerging pathogens. This approach could revolutionize veterinary vaccinology by offering enhanced efficacy and cross-protection against heterologous infections, particularly valuable for zoonotic disease control. |
| format | Article |
| id | doaj-art-24deb30e86a249eab5cfec53344e673b |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-24deb30e86a249eab5cfec53344e673b2025-01-15T14:35:14ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15246681524668Advancing veterinary vaccines design through trained immunity insightsXin Wang0Xin Wang1Xin Wang2Xin Wang3Guohua Yu4Guohua Yu5Guohua Yu6College of Life Science, Longyan University, Longyan, ChinaFujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnolog, Longyan, ChinaKey Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University, Longyan, ChinaChinese International College, Dhurakij Pundit University, Bangkok, ThailandCollege of Life Science, Longyan University, Longyan, ChinaFujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnolog, Longyan, ChinaKey Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University, Longyan, ChinaTrained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. This perspective examines how trained immunity can be integrated into veterinary vaccine design through metabolic reprogramming and epigenetic modifications. We analyze key molecular mechanisms, including the shift to aerobic glycolysis and sustained epigenetic changes, that enable enhanced immune responses. Strategic approaches for vaccine optimization are proposed, focusing on selecting effective trained immunity inducers, developing innovative adjuvant systems, and achieving synergistic enhancement of immune responses. While implementation challenges exist, including individual response variations and safety considerations, trained immunity-based vaccines show potential for providing broader protection against emerging pathogens. This approach could revolutionize veterinary vaccinology by offering enhanced efficacy and cross-protection against heterologous infections, particularly valuable for zoonotic disease control.https://www.frontiersin.org/articles/10.3389/fvets.2024.1524668/fulltrained immunityinnate immune memorymetabolic reprogrammingepigenetic modificationveterinary vaccines |
| spellingShingle | Xin Wang Xin Wang Xin Wang Xin Wang Guohua Yu Guohua Yu Guohua Yu Advancing veterinary vaccines design through trained immunity insights Frontiers in Veterinary Science trained immunity innate immune memory metabolic reprogramming epigenetic modification veterinary vaccines |
| title | Advancing veterinary vaccines design through trained immunity insights |
| title_full | Advancing veterinary vaccines design through trained immunity insights |
| title_fullStr | Advancing veterinary vaccines design through trained immunity insights |
| title_full_unstemmed | Advancing veterinary vaccines design through trained immunity insights |
| title_short | Advancing veterinary vaccines design through trained immunity insights |
| title_sort | advancing veterinary vaccines design through trained immunity insights |
| topic | trained immunity innate immune memory metabolic reprogramming epigenetic modification veterinary vaccines |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1524668/full |
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