Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia
Dengue fever is an increasing health problem in tropical and subtropical regions. During 2010 in Medellin, the younger population presented a particularly high dengue incidence rate. This study estimated dengue virus (DENV) transmission in schoolchildren (aged 5–19 years) in Medellin from 2010 to 20...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2018/2308095 |
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| author | Leidy Diana Piedrahita Ivony Y. Agudelo Salas Katherine Marin Andrea I. Trujillo Jorge E. Osorio Sair Orieta Arboleda-Sanchez Berta Nelly Restrepo |
| author_facet | Leidy Diana Piedrahita Ivony Y. Agudelo Salas Katherine Marin Andrea I. Trujillo Jorge E. Osorio Sair Orieta Arboleda-Sanchez Berta Nelly Restrepo |
| author_sort | Leidy Diana Piedrahita |
| collection | DOAJ |
| description | Dengue fever is an increasing health problem in tropical and subtropical regions. During 2010 in Medellin, the younger population presented a particularly high dengue incidence rate. This study estimated dengue virus (DENV) transmission in schoolchildren (aged 5–19 years) in Medellin from 2010 to 2012. A longitudinal serological survey (IgG) and spatial analysis were conducted to determine the distribution of DENV seroprevalence. A total of 4,385 schoolchildren participated for at least one year. Dengue seroprevalence significantly increased during the studied period (53.8% to 64.6%; p<0.001). A significantly higher seroconversion rate was observed in 2010-2011 (16.8%) compared to 2011-2012 (7.8%). Multivariate regression analysis showed that the main factor associated with the seroprevalence was the aging. Furthermore, in 2010, patients with high socioeconomic status presented a lower risk. Predominant multitypic and DENV4 monotypic antibody responses were demonstrated. Geostatistical analysis evidenced a temporal clustering distribution of DENV seroprevalence in 2010. Population density and Ae. aegypti House Index were significantly correlated with the observed pattern. This study revealed high DENV transmission in schoolchildren determined as “sentinel population.” High DENV risk was found in districts with combined poorly socioeconomic conditions and densest human and mosquito populations. These findings may allow to target population for effective prevention and vaccination campaigns. |
| format | Article |
| id | doaj-art-24d2567a70af404bab38078a1c343bfb |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-24d2567a70af404bab38078a1c343bfb2025-02-03T00:58:54ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932018-01-01201810.1155/2018/23080952308095Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, ColombiaLeidy Diana Piedrahita0Ivony Y. Agudelo Salas1Katherine Marin2Andrea I. Trujillo3Jorge E. Osorio4Sair Orieta Arboleda-Sanchez5Berta Nelly Restrepo6Instituto Colombiano de Medicina Tropical, Universidad CES, Carrera 43 No. 52 Sur–99, Sabaneta, Antioquia 055450, ColombiaInstituto Colombiano de Medicina Tropical, Universidad CES, Carrera 43 No. 52 Sur–99, Sabaneta, Antioquia 055450, ColombiaInstituto Colombiano de Medicina Tropical, Universidad CES, Carrera 43 No. 52 Sur–99, Sabaneta, Antioquia 055450, ColombiaDepartment of Pathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Drive, Madison, WI 53706, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Drive, Madison, WI 53706, USAGrupo de Biología y Control de Enfermedades Infecciosas -BCEI, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Antioquia 050010, ColombiaInstituto Colombiano de Medicina Tropical, Universidad CES, Carrera 43 No. 52 Sur–99, Sabaneta, Antioquia 055450, ColombiaDengue fever is an increasing health problem in tropical and subtropical regions. During 2010 in Medellin, the younger population presented a particularly high dengue incidence rate. This study estimated dengue virus (DENV) transmission in schoolchildren (aged 5–19 years) in Medellin from 2010 to 2012. A longitudinal serological survey (IgG) and spatial analysis were conducted to determine the distribution of DENV seroprevalence. A total of 4,385 schoolchildren participated for at least one year. Dengue seroprevalence significantly increased during the studied period (53.8% to 64.6%; p<0.001). A significantly higher seroconversion rate was observed in 2010-2011 (16.8%) compared to 2011-2012 (7.8%). Multivariate regression analysis showed that the main factor associated with the seroprevalence was the aging. Furthermore, in 2010, patients with high socioeconomic status presented a lower risk. Predominant multitypic and DENV4 monotypic antibody responses were demonstrated. Geostatistical analysis evidenced a temporal clustering distribution of DENV seroprevalence in 2010. Population density and Ae. aegypti House Index were significantly correlated with the observed pattern. This study revealed high DENV transmission in schoolchildren determined as “sentinel population.” High DENV risk was found in districts with combined poorly socioeconomic conditions and densest human and mosquito populations. These findings may allow to target population for effective prevention and vaccination campaigns.http://dx.doi.org/10.1155/2018/2308095 |
| spellingShingle | Leidy Diana Piedrahita Ivony Y. Agudelo Salas Katherine Marin Andrea I. Trujillo Jorge E. Osorio Sair Orieta Arboleda-Sanchez Berta Nelly Restrepo Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia |
| title_full | Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia |
| title_fullStr | Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia |
| title_full_unstemmed | Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia |
| title_short | Risk Factors Associated with Dengue Transmission and Spatial Distribution of High Seroprevalence in Schoolchildren from the Urban Area of Medellin, Colombia |
| title_sort | risk factors associated with dengue transmission and spatial distribution of high seroprevalence in schoolchildren from the urban area of medellin colombia |
| url | http://dx.doi.org/10.1155/2018/2308095 |
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