Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
Objective To determine the association of allergic conditions with incident rheumatoid arthritis (RA), especially in relation to smoking history and anti-citrullinated peptide antibody (ACPA) status.Methods This case–control study included 3515 incident RA cases and 5429 matched controls from the Ep...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-02-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/8/1/e002018.full |
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| author | Johan Askling Lars Klareskog Lars Alfredsson Marie Holmqvist Helga Westerlind Cynthia S Crowson Vanessa L Kronzer |
| author_facet | Johan Askling Lars Klareskog Lars Alfredsson Marie Holmqvist Helga Westerlind Cynthia S Crowson Vanessa L Kronzer |
| author_sort | Johan Askling |
| collection | DOAJ |
| description | Objective To determine the association of allergic conditions with incident rheumatoid arthritis (RA), especially in relation to smoking history and anti-citrullinated peptide antibody (ACPA) status.Methods This case–control study included 3515 incident RA cases and 5429 matched controls from the Epidemiological Investigation of Rheumatoid Arthritis study 1995 to 2016, including questionnaire-based information on eight allergic conditions composed from a list of 59 unique allergies. We used logistic regression and adjusted ORs (aOR) to assess the association between allergic conditions and risk of RA, adjusting for age, sex, residential area, body mass index, education, and smoking, and stratified by smoking and ACPA.Results A history of any reported allergy was equally common in RA (n=1047, 30%) as among population controls (n=1540, 29%), aOR 1.04, 95% CI 0.95 to 1.15. Metal, respiratory, food, plant/pollen and chemical allergies were not associated with risk of RA. By contrast, statistically significant associations were observed for animal dander allergy (6% vs 5%, aOR 1.37, 95% CI 1.03 to 1.82), especially in ACPA-positive RA (aOR 1.46 95% CI 1.06 to 2.01) and for atopic dermatitis, in particular for older and ACPA-negative RA (aOR 2.33, 95% CI 1.37 to 3.96 at age 80). Never smokers with allergic rhinitis also had increased risk of developing RA (aOR 1.30, 95% CI 1.00 to 1.68).Conclusion Most common allergies do not increase risk of RA, nor do they protect against RA. However, some allergic conditions, notably animal dander allergy, atopic dermatitis and allergic rhinitis, were associated with an increased risk for RA. |
| format | Article |
| id | doaj-art-24cfa5b3e9a54bb6b160e7ba09936414 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-24cfa5b3e9a54bb6b160e7ba099364142025-02-06T16:50:12ZengBMJ Publishing GroupRMD Open2056-59332022-02-018110.1136/rmdopen-2021-002018Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control studyJohan Askling0Lars Klareskog1Lars Alfredsson2Marie Holmqvist3Helga Westerlind4Cynthia S Crowson5Vanessa L Kronzer6Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden5 Rheumatology Unit, Department of Medicine, Karolinska Institute, Solna, Stockholm, SwedenClinical Epidemiology Unit, Dept of Medicine Solna, Karolinska Institutet, Stockholm, Sweden2 Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, SwedenClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden1 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA2 Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USAObjective To determine the association of allergic conditions with incident rheumatoid arthritis (RA), especially in relation to smoking history and anti-citrullinated peptide antibody (ACPA) status.Methods This case–control study included 3515 incident RA cases and 5429 matched controls from the Epidemiological Investigation of Rheumatoid Arthritis study 1995 to 2016, including questionnaire-based information on eight allergic conditions composed from a list of 59 unique allergies. We used logistic regression and adjusted ORs (aOR) to assess the association between allergic conditions and risk of RA, adjusting for age, sex, residential area, body mass index, education, and smoking, and stratified by smoking and ACPA.Results A history of any reported allergy was equally common in RA (n=1047, 30%) as among population controls (n=1540, 29%), aOR 1.04, 95% CI 0.95 to 1.15. Metal, respiratory, food, plant/pollen and chemical allergies were not associated with risk of RA. By contrast, statistically significant associations were observed for animal dander allergy (6% vs 5%, aOR 1.37, 95% CI 1.03 to 1.82), especially in ACPA-positive RA (aOR 1.46 95% CI 1.06 to 2.01) and for atopic dermatitis, in particular for older and ACPA-negative RA (aOR 2.33, 95% CI 1.37 to 3.96 at age 80). Never smokers with allergic rhinitis also had increased risk of developing RA (aOR 1.30, 95% CI 1.00 to 1.68).Conclusion Most common allergies do not increase risk of RA, nor do they protect against RA. However, some allergic conditions, notably animal dander allergy, atopic dermatitis and allergic rhinitis, were associated with an increased risk for RA.https://rmdopen.bmj.com/content/8/1/e002018.full |
| spellingShingle | Johan Askling Lars Klareskog Lars Alfredsson Marie Holmqvist Helga Westerlind Cynthia S Crowson Vanessa L Kronzer Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study RMD Open |
| title | Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study |
| title_full | Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study |
| title_fullStr | Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study |
| title_full_unstemmed | Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study |
| title_short | Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study |
| title_sort | allergic conditions and risk of rheumatoid arthritis a swedish case control study |
| url | https://rmdopen.bmj.com/content/8/1/e002018.full |
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