A Novel Dual Bruton's Tyrosine Kinase/Janus Kinase 3 Inhibitor Wj1113 and its Therapeutic Effects on Rheumatoid Arthritis

A Novel Dual Bruton's Tyrosine Kinase/Janus Kinase 3 Inhibitor Wj1113 and its Therapeutic Effects on Rheumatoid Arthritis

ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and tissue damage, driven by dysregulated cytokine signaling and immune cell hyperactivation. Bruton's tyrosine kinase (BTK) mediates pathogenic B‐cell activation and autoantibody production,...

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Bibliographic Details
Main Authors: Chunyu Zhang, Fangfang Lai, Hang Gong, Shuying Li, Nan Xiang, Liuyi Que, Nina Xue, Mengyao Hao, Enjia Zhou, Xiaojian Wang, Taigang Liang, Jing Jin
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:MedComm
Subjects:
BTK
CIA
dual inhibitor
JAK3
RA
Online Access:https://doi.org/10.1002/mco2.70207
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