Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis
Introduction: This review article aims to evaluate the antibacterial efficacy of Aloe vera against Enterococcus faecalis (E. faecalis) in comparison to other intracanal medicaments by assessing experimental in-vitro studies associated with the objective, many of which performed bacterial inoculation...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-07-01
|
| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223000883 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196022575235072 |
|---|---|
| author | Rabia Tariq Zohaib Khurshid Waqas Ahmed Farooqui Nejdet Adanir |
| author_facet | Rabia Tariq Zohaib Khurshid Waqas Ahmed Farooqui Nejdet Adanir |
| author_sort | Rabia Tariq |
| collection | DOAJ |
| description | Introduction: This review article aims to evaluate the antibacterial efficacy of Aloe vera against Enterococcus faecalis (E. faecalis) in comparison to other intracanal medicaments by assessing experimental in-vitro studies associated with the objective, many of which performed bacterial inoculation on extracted human teeth or directly on laboratory petri dishes. Materials & Methods: Publications from 2012 to 2022 were retrieved from databases, including PubMed, Scopus, and Cochrane Library, and they were screened against our inclusion criteria, leading to the incorporation of 18 studies into the systematic review and nine into the meta-analysis. Colony-forming units (CFUs) in the Aloe vera group were compared with saline, sodium hypochlorite (NaOCl), chlorhexidine (CHX), and calcium hydroxide (CaOH) using a meta-analysis (Stata software version 16.0), and forest plots were computed to record the sample size, mean and standard deviation value of the outcome CFU, and 95% confidence intervals. Results: This systematic review indicates that Aloe vera demonstrates bactericidal properties that are higher than or similar to those of saline and CaOH, but CHX, NaOCl, and propolis exhibited higher antibacterial properties against E. faecalis than Aloe vera. In a meta-analysis, Aloe vera showed a non-significantly lower CFU count than CaOH and saline (p > 0.05), while Aloe vera had a higher CFU count than CHX and NaOCl (p > 0.05). Conclusion: In summary, Aloe vera exhibits antibacterial capabilities against E. faecalis that are superior or equal to those of saline and CaOH, respectively, while CHX and NaOCl showed greater antibacterial efficacy against E. faecalis than Aloe vera (PROSPERO registration no. CRD42022314790). |
| format | Article |
| id | doaj-art-24cbfbe730d64ec0be97c9d05e808c8c |
| institution | OA Journals |
| issn | 1013-9052 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-24cbfbe730d64ec0be97c9d05e808c8c2025-08-20T02:13:35ZengSpringerSaudi Dental Journal1013-90522023-07-0135545146710.1016/j.sdentj.2023.05.007Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysisRabia Tariq0Zohaib Khurshid1Waqas Ahmed Farooqui2Nejdet Adanir3Department of Research, School of Public Health, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al Ahsa 31982, Saudi Arabia; Center of Excellence for Regenerative Dentistry, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand; Corresponding author at: Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsan 31982, Saudi Arabia.School of Public Health, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Restorative Dentistry, College of Dentistry, King Faisal University, Al Ahsa 31982, Saudi ArabiaIntroduction: This review article aims to evaluate the antibacterial efficacy of Aloe vera against Enterococcus faecalis (E. faecalis) in comparison to other intracanal medicaments by assessing experimental in-vitro studies associated with the objective, many of which performed bacterial inoculation on extracted human teeth or directly on laboratory petri dishes. Materials & Methods: Publications from 2012 to 2022 were retrieved from databases, including PubMed, Scopus, and Cochrane Library, and they were screened against our inclusion criteria, leading to the incorporation of 18 studies into the systematic review and nine into the meta-analysis. Colony-forming units (CFUs) in the Aloe vera group were compared with saline, sodium hypochlorite (NaOCl), chlorhexidine (CHX), and calcium hydroxide (CaOH) using a meta-analysis (Stata software version 16.0), and forest plots were computed to record the sample size, mean and standard deviation value of the outcome CFU, and 95% confidence intervals. Results: This systematic review indicates that Aloe vera demonstrates bactericidal properties that are higher than or similar to those of saline and CaOH, but CHX, NaOCl, and propolis exhibited higher antibacterial properties against E. faecalis than Aloe vera. In a meta-analysis, Aloe vera showed a non-significantly lower CFU count than CaOH and saline (p > 0.05), while Aloe vera had a higher CFU count than CHX and NaOCl (p > 0.05). Conclusion: In summary, Aloe vera exhibits antibacterial capabilities against E. faecalis that are superior or equal to those of saline and CaOH, respectively, while CHX and NaOCl showed greater antibacterial efficacy against E. faecalis than Aloe vera (PROSPERO registration no. CRD42022314790).http://www.sciencedirect.com/science/article/pii/S1013905223000883Aloe veraBacteriaDisinfectionE. faecalisEndodonticIntracanal medicament |
| spellingShingle | Rabia Tariq Zohaib Khurshid Waqas Ahmed Farooqui Nejdet Adanir Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis Saudi Dental Journal Aloe vera Bacteria Disinfection E. faecalis Endodontic Intracanal medicament |
| title | Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis |
| title_full | Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis |
| title_fullStr | Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis |
| title_full_unstemmed | Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis |
| title_short | Anti-bacterial efficacy of Aloe vera against E. Faecalis in comparison to other intracanal medicaments: A systematic review and meta-analysis |
| title_sort | anti bacterial efficacy of aloe vera against e faecalis in comparison to other intracanal medicaments a systematic review and meta analysis |
| topic | Aloe vera Bacteria Disinfection E. faecalis Endodontic Intracanal medicament |
| url | http://www.sciencedirect.com/science/article/pii/S1013905223000883 |
| work_keys_str_mv | AT rabiatariq antibacterialefficacyofaloeveraagainstefaecalisincomparisontootherintracanalmedicamentsasystematicreviewandmetaanalysis AT zohaibkhurshid antibacterialefficacyofaloeveraagainstefaecalisincomparisontootherintracanalmedicamentsasystematicreviewandmetaanalysis AT waqasahmedfarooqui antibacterialefficacyofaloeveraagainstefaecalisincomparisontootherintracanalmedicamentsasystematicreviewandmetaanalysis AT nejdetadanir antibacterialefficacyofaloeveraagainstefaecalisincomparisontootherintracanalmedicamentsasystematicreviewandmetaanalysis |