Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex

The selective adsorption and separation of benzene from structurally similar six-membered hydrocarbons and fluorocarbons remain a significant challenge due to their comparable physical properties. In this study, we investigated the molecular recognition and separation properties of a perfluorinated...

Full description

Saved in:
Bibliographic Details
Main Authors: Kazuki Shiomoto, Nanako Oimatsu, Satoshi Hirano, Akiko Hori
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Crystals
Subjects:
Online Access:https://www.mdpi.com/2073-4352/15/4/322
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850183341376012288
author Kazuki Shiomoto
Nanako Oimatsu
Satoshi Hirano
Akiko Hori
author_facet Kazuki Shiomoto
Nanako Oimatsu
Satoshi Hirano
Akiko Hori
author_sort Kazuki Shiomoto
collection DOAJ
description The selective adsorption and separation of benzene from structurally similar six-membered hydrocarbons and fluorocarbons remain a significant challenge due to their comparable physical properties. In this study, we investigated the molecular recognition and separation properties of a perfluorinated triketonate Cu(II) complex (<b>1</b>) as a Nonporous Adaptive Crystal (NAC). In addition to the previously reported benzene (<b>2</b>)-encapsulated crystal of <b>1</b>•(<b>2</b>)<sub>3</sub>, we report here the crystal structures of guest-free <b>1</b> and cyclohexene (<b>3</b>)-encapsulated <b>1</b>•(O)<sub>2</sub>•<b>3</b>, where (O)<sub>2</sub> represents two water molecules. Single-crystal analysis demonstrated that <b>1</b> selectively encapsulates <b>2</b> while excluding other hydrocarbons, including <b>3</b>, cyclohexane (<b>4</b>), trifluorobenzene (<b>5</b>), and hexafluorobenzene (<b>6</b>). Gas adsorption experiments confirmed this high affinity for <b>2</b>, as reflected in its preferential adsorption behavior in mixed solvent and vapor environments. The molecular selectivity of <b>1</b> was attributed to strong π-hole···π and metal···π interactions, which favor electron-rich aromatic guests. Additionally, crystallization experiments in competitive solvent systems consistently led to the formation of <b>1</b>•(<b>2</b>)<sub>3</sub>, reinforcing the high selectivity of <b>1</b> for <b>2</b>. These findings highlight the unique molecular recognition capabilities of NACs, providing valuable insights into the rational design of advanced molecular separation materials for industrial applications involving aromatic hydrocarbons. Hirshfeld surface analysis revealed that the contribution of F···F interactions to crystal packing decreased upon guest recognition (48.8% in <b>1</b>, 34.2% in <b>1</b>•(O)<sub>2</sub>•<b>3</b>, and 22.2% in <b>1</b>•(<b>2</b>)<sub>3</sub>), while the contribution of F···H/H···F interactions increased (8.6% in <b>1</b>, 22.2% in <b>1</b>•(O)<sub>2</sub>•<b>3</b>, and 35.4% in <b>1</b>•(<b>2</b>)<sub>3</sub>). Regarding Cu interactions, the self-assembled columnar structure of <b>1</b> results in close contacts at the coordination sites, including Cu···Cu (0.1%), Cu···O (0.7%), and Cu···C (1.3%). However, in the guest-incorporated structures <b>1</b>•(O)<sub>2</sub>•<b>3</b> and <b>1</b>•(<b>2</b>)<sub>3</sub>, the Cu···Cu contribution disappears; instead, <b>1</b>•(O)<sub>2</sub>•<b>3</b> exhibits a significant increase in Cu···O interactions (1.2%), corresponding to water coordination, while <b>1</b>•(<b>2</b>)<sub>3</sub> shows an increase in Cu···C interactions (1.5%), indicative of the metal···π interactions of benzene.
format Article
id doaj-art-24cb874cdbbc4e0e9d88647b9c48b860
institution OA Journals
issn 2073-4352
language English
publishDate 2025-03-01
publisher MDPI AG
record_format Article
series Crystals
spelling doaj-art-24cb874cdbbc4e0e9d88647b9c48b8602025-08-20T02:17:24ZengMDPI AGCrystals2073-43522025-03-0115432210.3390/cryst15040322Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) ComplexKazuki Shiomoto0Nanako Oimatsu1Satoshi Hirano2Akiko Hori3Department of Applied Chemistry, Graduate School of Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, JapanDepartment of Applied Chemistry, Graduate School of Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, JapanDepartment of Applied Chemistry, Graduate School of Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, JapanDepartment of Applied Chemistry, Graduate School of Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, JapanThe selective adsorption and separation of benzene from structurally similar six-membered hydrocarbons and fluorocarbons remain a significant challenge due to their comparable physical properties. In this study, we investigated the molecular recognition and separation properties of a perfluorinated triketonate Cu(II) complex (<b>1</b>) as a Nonporous Adaptive Crystal (NAC). In addition to the previously reported benzene (<b>2</b>)-encapsulated crystal of <b>1</b>•(<b>2</b>)<sub>3</sub>, we report here the crystal structures of guest-free <b>1</b> and cyclohexene (<b>3</b>)-encapsulated <b>1</b>•(O)<sub>2</sub>•<b>3</b>, where (O)<sub>2</sub> represents two water molecules. Single-crystal analysis demonstrated that <b>1</b> selectively encapsulates <b>2</b> while excluding other hydrocarbons, including <b>3</b>, cyclohexane (<b>4</b>), trifluorobenzene (<b>5</b>), and hexafluorobenzene (<b>6</b>). Gas adsorption experiments confirmed this high affinity for <b>2</b>, as reflected in its preferential adsorption behavior in mixed solvent and vapor environments. The molecular selectivity of <b>1</b> was attributed to strong π-hole···π and metal···π interactions, which favor electron-rich aromatic guests. Additionally, crystallization experiments in competitive solvent systems consistently led to the formation of <b>1</b>•(<b>2</b>)<sub>3</sub>, reinforcing the high selectivity of <b>1</b> for <b>2</b>. These findings highlight the unique molecular recognition capabilities of NACs, providing valuable insights into the rational design of advanced molecular separation materials for industrial applications involving aromatic hydrocarbons. Hirshfeld surface analysis revealed that the contribution of F···F interactions to crystal packing decreased upon guest recognition (48.8% in <b>1</b>, 34.2% in <b>1</b>•(O)<sub>2</sub>•<b>3</b>, and 22.2% in <b>1</b>•(<b>2</b>)<sub>3</sub>), while the contribution of F···H/H···F interactions increased (8.6% in <b>1</b>, 22.2% in <b>1</b>•(O)<sub>2</sub>•<b>3</b>, and 35.4% in <b>1</b>•(<b>2</b>)<sub>3</sub>). Regarding Cu interactions, the self-assembled columnar structure of <b>1</b> results in close contacts at the coordination sites, including Cu···Cu (0.1%), Cu···O (0.7%), and Cu···C (1.3%). However, in the guest-incorporated structures <b>1</b>•(O)<sub>2</sub>•<b>3</b> and <b>1</b>•(<b>2</b>)<sub>3</sub>, the Cu···Cu contribution disappears; instead, <b>1</b>•(O)<sub>2</sub>•<b>3</b> exhibits a significant increase in Cu···O interactions (1.2%), corresponding to water coordination, while <b>1</b>•(<b>2</b>)<sub>3</sub> shows an increase in Cu···C interactions (1.5%), indicative of the metal···π interactions of benzene.https://www.mdpi.com/2073-4352/15/4/322co-crystalcrystal growthfluorine effectπ-holemolecular recognition
spellingShingle Kazuki Shiomoto
Nanako Oimatsu
Satoshi Hirano
Akiko Hori
Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex
Crystals
co-crystal
crystal growth
fluorine effect
π-hole
molecular recognition
title Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex
title_full Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex
title_fullStr Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex
title_full_unstemmed Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex
title_short Selective Benzene Recognition in Competitive Solvent System (Cyclohexene, Cyclohexane, Tri- and Hexafluorobenzenes) Using Perfluorinated Dinuclear Cu(II) Complex
title_sort selective benzene recognition in competitive solvent system cyclohexene cyclohexane tri and hexafluorobenzenes using perfluorinated dinuclear cu ii complex
topic co-crystal
crystal growth
fluorine effect
π-hole
molecular recognition
url https://www.mdpi.com/2073-4352/15/4/322
work_keys_str_mv AT kazukishiomoto selectivebenzenerecognitionincompetitivesolventsystemcyclohexenecyclohexanetriandhexafluorobenzenesusingperfluorinateddinuclearcuiicomplex
AT nanakooimatsu selectivebenzenerecognitionincompetitivesolventsystemcyclohexenecyclohexanetriandhexafluorobenzenesusingperfluorinateddinuclearcuiicomplex
AT satoshihirano selectivebenzenerecognitionincompetitivesolventsystemcyclohexenecyclohexanetriandhexafluorobenzenesusingperfluorinateddinuclearcuiicomplex
AT akikohori selectivebenzenerecognitionincompetitivesolventsystemcyclohexenecyclohexanetriandhexafluorobenzenesusingperfluorinateddinuclearcuiicomplex