Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice
The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist) on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the contr...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/983651 |
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| author | Quratulane Gillani Shahid Iqbal Fatima Arfa Saba Khakwani Atif Akbar Asmat Ullah Muhammad Ali Furhan Iqbal |
| author_facet | Quratulane Gillani Shahid Iqbal Fatima Arfa Saba Khakwani Atif Akbar Asmat Ullah Muhammad Ali Furhan Iqbal |
| author_sort | Quratulane Gillani |
| collection | DOAJ |
| description | The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist) on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution. A battery of neurological tests was applied following the intrapertoneal injections. Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528) and female (P=0.125) albino mice. CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04), time immobile (P=0.04), rotations (P=0.04), and anticlockwise rotations (P=0.038)). The results for Morris water maze (MWM) retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04) than control indicating improved memory. This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded. |
| format | Article |
| id | doaj-art-24c01361dbaa480ca801f6f8723ee11f |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-24c01361dbaa480ca801f6f8723ee11f2025-08-20T02:04:38ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/983651983651Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino MiceQuratulane Gillani0Shahid Iqbal1Fatima Arfa2Saba Khakwani3Atif Akbar4Asmat Ullah5Muhammad Ali6Furhan Iqbal7Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, PakistanZoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, PakistanZoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, PakistanZoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Statistics, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Zoology, Quaid-I-Azam Campus, Punjab University, Lahore 54000, PakistanInstitute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan 60800, PakistanZoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, PakistanThe present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist) on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution. A battery of neurological tests was applied following the intrapertoneal injections. Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528) and female (P=0.125) albino mice. CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04), time immobile (P=0.04), rotations (P=0.04), and anticlockwise rotations (P=0.038)). The results for Morris water maze (MWM) retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04) than control indicating improved memory. This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded.http://dx.doi.org/10.1155/2014/983651 |
| spellingShingle | Quratulane Gillani Shahid Iqbal Fatima Arfa Saba Khakwani Atif Akbar Asmat Ullah Muhammad Ali Furhan Iqbal Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice The Scientific World Journal |
| title | Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice |
| title_full | Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice |
| title_fullStr | Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice |
| title_full_unstemmed | Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice |
| title_short | Effect of GABAB Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice |
| title_sort | effect of gabab receptor antagonist cgp35348 on learning and memory in albino mice |
| url | http://dx.doi.org/10.1155/2014/983651 |
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