Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

IntroductionInflammatory bowel disease (IBD) is a complex disease that is characterized by tight junction loss and dysregulation of immune homeostasis. The repair of intestinal integrity and immune function in IBD remains a clinical challenge. Sphingosine-1-phosphate (S1P) has been reported to allev...

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Main Authors: Liang Hu, Zi Yang, Ying Zhang, Conglin Du, Yang Yang, Zhichao Chang, Xiangchun Li, Zhaochen Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
sphingosine-1-phosphate
inflammatory bowel disease
intestinal epithelial integrity
macrophage
PI3K-Akt signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622094/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622094/full

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