Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson’s Disease

Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson’s Disease

The present study examined whether crosstalk between cannabinoid (CB) and transient potential receptor vanilloid type 1 (TRPV1) could contribute to the survival of nigrostriatal dopamine neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD). MPTP...

Full description

Saved in:

Bibliographic Details
Main Authors:	Rayul Wi, Young Cheul Chung, Byung Kwan Jin
Format:	Article
Language:	English
Published:	Wiley 2020-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2020/5093493
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease
by: Young Cheul Chung, et al.
Published: (2013-01-01)

Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP+/MPTP-Lesioned Dopaminergic Neurons.
by: Pabla Aguirre, et al.
Published: (2015-01-01)

Urinary Dysfunction Is Associated with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson’s Disease
by: Jing Wang, et al.
Published: (2020-01-01)

Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway
by: Joshua Peter, et al.
Published: (2025-09-01)

Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence
by: A. Machado, et al.
Published: (2011-01-01)

Nigrostriatal iron accumulation in the progression of Parkinson’s disease
by: M. López-Aguirre, et al.
Published: (2025-04-01)

REV-ERBα inhibitor rescues MPTP/MPP+-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway
by: Xiaoyu Wang, et al.
Published: (2024-12-01)

CB2 and TRPV1 receptors in inflammatory state of macrophages from sickle cell anemia pediatric/young adults
by: Giuseppe Di Feo, et al.
Published: (2025-08-01)

Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis.
by: Alisdair McNeill, et al.
Published: (2013-01-01)

Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review
by: Shahid Ishaq, et al.
Published: (2025-02-01)

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress.
by: Rajib Paul, et al.
Published: (2017-01-01)

Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson’s Disease
by: Yanqin Wang, et al.
Published: (2017-01-01)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons.
by: Jacqueline A Bayliss, et al.
Published: (2016-01-01)

Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients
by: Rubén Fernández‐Santiago, et al.
Published: (2015-10-01)

Unraveling the mystery: How autophagy deficiency in dopaminergic neurons drives human Parkinson’s disease
by: Sachiko Noda, et al.
Published: (2025-07-01)

The effect of cannabinoid type Ⅱ receptor on the excitability of substantia nigra dopaminergic neurons
by: Sha Zhao, et al.
Published: (2025-02-01)

Subtle behavioral alterations in the spontaneous behaviors of MPTP mouse model of Parkinson’s disease
by: Hao Zhong, et al.
Published: (2025-04-01)

Dyrk1a Phosphorylation of α-Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson’s Disease
by: Yuxuan Yong, et al.
Published: (2023-01-01)

Proteomic insights into the biology of dopaminergic neurons
by: Claudia Cavarischia-Rega, et al.
Published: (2025-07-01)

GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson’s disease with RBD
by: Youmin Zhang, et al.
Published: (2025-08-01)

Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells.
by: Claudia Compagnucci, et al.
Published: (2013-01-01)

Gardenia-derived extracellular vesicles exert therapeutic effects on dopaminergic neuron apoptosis-mediated Parkinson’s disease
by: Wen Chen, et al.
Published: (2025-07-01)

The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson’s Disease Model Mice
by: Qiaoyun Dong, et al.
Published: (2015-01-01)

Parkinson's Disease Modeling Using Directly Converted 3D Induced Dopaminergic Neuron Organoids and Assembloids
by: Hongwon Kim, et al.
Published: (2025-04-01)

MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss
by: Alise Zagare, et al.
Published: (2025-04-01)

An optimized method for counting dopaminergic neurons in zebrafish.
by: Hideaki Matsui, et al.
Published: (2017-01-01)

Activation of cannabinoid CB1 receptors suppresses HCN channels function in dorsal root ganglion neurons of rats
by: Xiaolu Lei, et al.
Published: (2025-09-01)

Efficient Reprogramming of Mouse Fibroblasts to Neuronal Cells including Dopaminergic Neurons
by: Seung-ick Oh, et al.
Published: (2014-01-01)

Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease
by: Xi Luo, et al.
Published: (2025-06-01)

Effect of Swimming Training with Hesperidin on Gene Expression Related Dopaminergic Neuron Survival in an Animal Model of Parkinson\'s Disease
by: Asma Taraz, et al.
Published: (2025-08-01)

Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease
by: Bérengère Ballion, et al.
Published: (2025-05-01)

Dopaminergic Modulation of Prospective Memory in Parkinson’s Disease
by: Alberto Costa, et al.
Published: (2008-01-01)

Effect of dopaminergic therapy on lacrimation in Parkinson's disease
by: A. A. Pilipovich, et al.
Published: (2023-12-01)

Accurate Chemogenetics Determines Electroacupuncture Analgesia Through Increased CB1 to Suppress the TRPV1 Pathway in a Mouse Model of Fibromyalgia
by: Huan-Chin Lin, et al.
Published: (2025-05-01)

Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson's disease.
by: Michel Modo, et al.
Published: (2017-01-01)

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay
by: Leire Borrega-Roman, et al.
Published: (2025-04-01)

CB1 receptor and psychosis: friend, foe, or both
by: Jagadeesh S. Rao, et al.
Published: (2025-07-01)

Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro.
by: Tuulia Saarenpää, et al.
Published: (2017-01-01)

Oligodendrocyte-astrocyte crosstalk in Parkinson’s disease mediates neuronal ferroptosis via the FGF signaling pathway
by: Sen Zhang, et al.
Published: (2025-05-01)

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells
by: Samuela Cataldi, et al.
Published: (2017-01-01)