Reevaluating anticoagulation therapy for sepsis-associated disseminated intravascular coagulation based on endothelial glycocalyx shedding quantification: a single-center, retrospective, observational pilot study

Reevaluating anticoagulation therapy for sepsis-associated disseminated intravascular coagulation based on endothelial glycocalyx shedding quantification: a single-center, retrospective, observational pilot study

BackgroundSepsis-induced disseminated intravascular coagulation (DIC) is associated with critical conditions and linked to a high mortality rate. Anticoagulants such as recombinant human soluble thrombomodulin (rhTM) and antithrombin are used to treat sepsis-associated DIC; however, their efficacy r...

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Bibliographic Details
Main Authors: Keiko Suzuki, Akio Suzuki, Kazuyuki Sumi, Kodai Suzuki, Tomoaki Yoshimura, Shozo Yoshida, Nobuyuki Tetsuka, Hideshi Okada
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
anticoagulant
disseminated intravascular coagulation
glycocalyx
sepsis
syndecan-1
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1566753/full
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