Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis
Abstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green and safe coating technology that functionalizes probiotics wi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411939 |
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| author | Yong Zhu Ziqu Fang Jie Bai Longhui Wang Jiaqing Chen Zehua Zhang Qiang Wang Weiwei Sheng Xueyin Pan Zhenyuan Gao Dengqiu Xu Pengkai Wu Beicheng Sun |
| author_facet | Yong Zhu Ziqu Fang Jie Bai Longhui Wang Jiaqing Chen Zehua Zhang Qiang Wang Weiwei Sheng Xueyin Pan Zhenyuan Gao Dengqiu Xu Pengkai Wu Beicheng Sun |
| author_sort | Yong Zhu |
| collection | DOAJ |
| description | Abstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green and safe coating technology that functionalizes probiotics with nanozymes while preserving the activity of both components remains a challenge. To address this, chitosan‐modified epigallocatechin gallate (EGCG‐CS, EC)is synthesized, leveraging the intrinsic adhesive and coordination properties of polyphenols to capture gold nanozymes (AuNPs), forming ECA complexes that enhance nanozyme activity. When coated onto Escherichia coli Nissle 1917 (EcN), the resulting ECA@EcN system effectively scavenged reactive oxygen species (ROS), improving probiotic viability and promoting colon accumulation. Mechanistically, ECA protected EcN by suppressing the activation of the Flagellar Assembly and Branched‐Chain Amino Acid Synthesis pathways, ultimately alleviating inflammation and modulating intestinal microbial communities to relieve IBD symptoms. Given the biocompatibility of its components and the environmentally friendly assembly approach, this polyphenol‐nanozyme‐armored probiotic system represents a promising platform for IBD treatment. |
| format | Article |
| id | doaj-art-24b6f32d82ec44d7a1f374d746a0b60b |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-24b6f32d82ec44d7a1f374d746a0b60b2025-08-20T03:48:47ZengWileyAdvanced Science2198-38442025-05-011217n/an/a10.1002/advs.202411939Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota DysbiosisYong Zhu0Ziqu Fang1Jie Bai2Longhui Wang3Jiaqing Chen4Zehua Zhang5Qiang Wang6Weiwei Sheng7Xueyin Pan8Zhenyuan Gao9Dengqiu Xu10Pengkai Wu11Beicheng Sun12Department of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaMOE Innovation Center for Basic Research in Tumor Immunotherapy Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 ChinaAbstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green and safe coating technology that functionalizes probiotics with nanozymes while preserving the activity of both components remains a challenge. To address this, chitosan‐modified epigallocatechin gallate (EGCG‐CS, EC)is synthesized, leveraging the intrinsic adhesive and coordination properties of polyphenols to capture gold nanozymes (AuNPs), forming ECA complexes that enhance nanozyme activity. When coated onto Escherichia coli Nissle 1917 (EcN), the resulting ECA@EcN system effectively scavenged reactive oxygen species (ROS), improving probiotic viability and promoting colon accumulation. Mechanistically, ECA protected EcN by suppressing the activation of the Flagellar Assembly and Branched‐Chain Amino Acid Synthesis pathways, ultimately alleviating inflammation and modulating intestinal microbial communities to relieve IBD symptoms. Given the biocompatibility of its components and the environmentally friendly assembly approach, this polyphenol‐nanozyme‐armored probiotic system represents a promising platform for IBD treatment.https://doi.org/10.1002/advs.202411939inflammatory bowel diseasenanozymepolyphenolprobiotics |
| spellingShingle | Yong Zhu Ziqu Fang Jie Bai Longhui Wang Jiaqing Chen Zehua Zhang Qiang Wang Weiwei Sheng Xueyin Pan Zhenyuan Gao Dengqiu Xu Pengkai Wu Beicheng Sun Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis Advanced Science inflammatory bowel disease nanozyme polyphenol probiotics |
| title | Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis |
| title_full | Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis |
| title_fullStr | Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis |
| title_full_unstemmed | Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis |
| title_short | Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis |
| title_sort | orally administered functional polyphenol nanozyme armored probiotics for enhanced amelioration of intestinal inflammation and microbiota dysbiosis |
| topic | inflammatory bowel disease nanozyme polyphenol probiotics |
| url | https://doi.org/10.1002/advs.202411939 |
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