Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development
BackgroundMigraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population.MethodsThe research analyzed specific genetic variations—TNF-α −308 G/A, TNF-α −857 C/T, TNF-α −238G/A...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1556498/full |
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| author | Guijiao Huang Xin Dong Xiaojiao Shao Mengping Wu Shan Gao Yixuan Wang Xinying Guan |
| author_facet | Guijiao Huang Xin Dong Xiaojiao Shao Mengping Wu Shan Gao Yixuan Wang Xinying Guan |
| author_sort | Guijiao Huang |
| collection | DOAJ |
| description | BackgroundMigraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population.MethodsThe research analyzed specific genetic variations—TNF-α −308 G/A, TNF-α −857 C/T, TNF-α −238G/A, IL1B-3953 C/T, and IL1RN −2018T/C SNPs—within 212 migraine patients and 210 healthy controls. Utilizing SNaPshot technology, scientists genotyped these markers related to TNF-α and IL-1 genes.ResultsFindings revealed a significant association between the IL1B−3953 C/T SNP and migraine susceptibility, particularly noting its link with a familial history of the disorder. The presence of the C allele at this location was more prevalent in migraine sufferers. Multivariate analysis reinforced this connection, indicating the C allele under a dominant model as an independent risk factor for migraine (OR = 2.315, 95%CI: 1.053–5.090, P = 0.037). Additionally, the study observed a sex-specific difference regarding the TNF-α −857 C/T SNP among migraine patients.ConclusionOverall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B−3953 C/T SNP as a potential biomarker for migraine susceptibility. |
| format | Article |
| id | doaj-art-24b08b70d42e4bc281f938682b3ed7fd |
| institution | DOAJ |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-24b08b70d42e4bc281f938682b3ed7fd2025-08-20T03:14:20ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-04-011610.3389/fgene.2025.15564981556498Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine developmentGuijiao Huang0Xin Dong1Xiaojiao Shao2Mengping Wu3Shan Gao4Yixuan Wang5Xinying Guan6Department of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University/ Lianyungang Training Base of Jinzhou Medical University/ The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, ChinaDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Clinical Medicine, The Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University/ Lianyungang Training Base of Jinzhou Medical University/ The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University/ Lianyungang Training Base of Jinzhou Medical University/ The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University/ Lianyungang Training Base of Jinzhou Medical University/ The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University/ Lianyungang Training Base of Jinzhou Medical University/ The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, ChinaBackgroundMigraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population.MethodsThe research analyzed specific genetic variations—TNF-α −308 G/A, TNF-α −857 C/T, TNF-α −238G/A, IL1B-3953 C/T, and IL1RN −2018T/C SNPs—within 212 migraine patients and 210 healthy controls. Utilizing SNaPshot technology, scientists genotyped these markers related to TNF-α and IL-1 genes.ResultsFindings revealed a significant association between the IL1B−3953 C/T SNP and migraine susceptibility, particularly noting its link with a familial history of the disorder. The presence of the C allele at this location was more prevalent in migraine sufferers. Multivariate analysis reinforced this connection, indicating the C allele under a dominant model as an independent risk factor for migraine (OR = 2.315, 95%CI: 1.053–5.090, P = 0.037). Additionally, the study observed a sex-specific difference regarding the TNF-α −857 C/T SNP among migraine patients.ConclusionOverall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B−3953 C/T SNP as a potential biomarker for migraine susceptibility.https://www.frontiersin.org/articles/10.3389/fgene.2025.1556498/fullinflammationinterleukins-1migrainetumor necrosis factor-alphasingle nucleotide polymorphisms |
| spellingShingle | Guijiao Huang Xin Dong Xiaojiao Shao Mengping Wu Shan Gao Yixuan Wang Xinying Guan Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development Frontiers in Genetics inflammation interleukins-1 migraine tumor necrosis factor-alpha single nucleotide polymorphisms |
| title | Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development |
| title_full | Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development |
| title_fullStr | Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development |
| title_full_unstemmed | Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development |
| title_short | Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development |
| title_sort | correlation of tumor necrosis factor α and interleukin 1 single nucleotide polymorphisms with the risk of migraine development |
| topic | inflammation interleukins-1 migraine tumor necrosis factor-alpha single nucleotide polymorphisms |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1556498/full |
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