Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody
We describe the case of a young woman who was referred to a tertiary care center with unexplained subacute progressive encephalopathy preceded by long-standing severe headaches. Her extensive workup was remarkable for abnormal intracranial angiography suggestive of small- and medium-vessel vasculiti...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/495201 |
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| author | Amer M. Awad Mathew Stevenson |
| author_facet | Amer M. Awad Mathew Stevenson |
| author_sort | Amer M. Awad |
| collection | DOAJ |
| description | We describe the case of a young woman who was referred to a tertiary care center with unexplained subacute progressive encephalopathy preceded by long-standing severe headaches. Her extensive workup was remarkable for abnormal intracranial angiography suggestive of small- and medium-vessel vasculitis, persistently elevated protein in the cerebrospinal fluid and persistently high titers of antiribonuclear protein antibody. The patient showed a modest response to intravenous high-dose steroids. We propose that the patient's neurologic disease is secondary to immune-mediated central nervous system vasculitis, possibly as an initial manifestation of mixed connective tissue disease. |
| format | Article |
| id | doaj-art-24af6157512e4fb09942122153891a8a |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-24af6157512e4fb09942122153891a8a2025-02-03T06:05:00ZengWileyCase Reports in Neurological Medicine2090-66682090-66762011-01-01201110.1155/2011/495201495201Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein AntibodyAmer M. Awad0Mathew Stevenson1Baton Rouge Neurology Associates, Baton Rouge General Medical Center, Baton Rouge, LA 70806, USADepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390-7208, USAWe describe the case of a young woman who was referred to a tertiary care center with unexplained subacute progressive encephalopathy preceded by long-standing severe headaches. Her extensive workup was remarkable for abnormal intracranial angiography suggestive of small- and medium-vessel vasculitis, persistently elevated protein in the cerebrospinal fluid and persistently high titers of antiribonuclear protein antibody. The patient showed a modest response to intravenous high-dose steroids. We propose that the patient's neurologic disease is secondary to immune-mediated central nervous system vasculitis, possibly as an initial manifestation of mixed connective tissue disease.http://dx.doi.org/10.1155/2011/495201 |
| spellingShingle | Amer M. Awad Mathew Stevenson Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody Case Reports in Neurological Medicine |
| title | Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody |
| title_full | Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody |
| title_fullStr | Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody |
| title_full_unstemmed | Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody |
| title_short | Isolated Central Nervous System Vasculitis Associated with Antiribonuclear Protein Antibody |
| title_sort | isolated central nervous system vasculitis associated with antiribonuclear protein antibody |
| url | http://dx.doi.org/10.1155/2011/495201 |
| work_keys_str_mv | AT amermawad isolatedcentralnervoussystemvasculitisassociatedwithantiribonuclearproteinantibody AT mathewstevenson isolatedcentralnervoussystemvasculitisassociatedwithantiribonuclearproteinantibody |