Complete Histological Resolution of Collagenous Sprue
A 65-year-old woman developed a watery diarrhea syndrome with collagenous colitis. Later, weight loss and hypoalbuminemia were documented. This prompted small bowel biopsies that showed pathological changes of collagenous sprue. An apparent treatment response to a gluten-free diet and prednisone res...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/961380 |
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| author | Hugh J Freeman Jennifer E Davis Danny M Myers |
| author_facet | Hugh J Freeman Jennifer E Davis Danny M Myers |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | A 65-year-old woman developed a watery diarrhea syndrome with collagenous colitis. Later, weight loss and hypoalbuminemia were documented. This prompted small bowel biopsies that showed pathological changes of collagenous sprue. An apparent treatment response to a gluten-free diet and prednisone resulted in reduced diarrhea, weight gain and normalization of serum albumin. Later repeated biopsies from multiple small and large bowel sites over a period of over three years, however, showed reversion to normal small intestinal mucosa but persistent collagenous colitis. These results indicate that collagenous inflammatory disease may be a far more extensive process in the gastrointestinal tract than is currently appreciated. Moreover, collagenous colitis may be a clinical signal that occult small intestinal disease is present. Finally, collagenous sprue may, in some instances, be a completely reversible small intestinal disorder. |
| format | Article |
| id | doaj-art-24adfca691444400a7c408d7716e97a1 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-24adfca691444400a7c408d7716e97a12025-02-03T01:01:50ZengWileyCanadian Journal of Gastroenterology0835-79002004-01-0118533333610.1155/2004/961380Complete Histological Resolution of Collagenous SprueHugh J Freeman0Jennifer E Davis1Danny M Myers2Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Pathology, University of British Columbia, Vancouver, British Columbia, CanadaShuswap Lake General Hospital, Salmon Arm, British Columbia, CanadaA 65-year-old woman developed a watery diarrhea syndrome with collagenous colitis. Later, weight loss and hypoalbuminemia were documented. This prompted small bowel biopsies that showed pathological changes of collagenous sprue. An apparent treatment response to a gluten-free diet and prednisone resulted in reduced diarrhea, weight gain and normalization of serum albumin. Later repeated biopsies from multiple small and large bowel sites over a period of over three years, however, showed reversion to normal small intestinal mucosa but persistent collagenous colitis. These results indicate that collagenous inflammatory disease may be a far more extensive process in the gastrointestinal tract than is currently appreciated. Moreover, collagenous colitis may be a clinical signal that occult small intestinal disease is present. Finally, collagenous sprue may, in some instances, be a completely reversible small intestinal disorder.http://dx.doi.org/10.1155/2004/961380 |
| spellingShingle | Hugh J Freeman Jennifer E Davis Danny M Myers Complete Histological Resolution of Collagenous Sprue Canadian Journal of Gastroenterology |
| title | Complete Histological Resolution of Collagenous Sprue |
| title_full | Complete Histological Resolution of Collagenous Sprue |
| title_fullStr | Complete Histological Resolution of Collagenous Sprue |
| title_full_unstemmed | Complete Histological Resolution of Collagenous Sprue |
| title_short | Complete Histological Resolution of Collagenous Sprue |
| title_sort | complete histological resolution of collagenous sprue |
| url | http://dx.doi.org/10.1155/2004/961380 |
| work_keys_str_mv | AT hughjfreeman completehistologicalresolutionofcollagenoussprue AT jenniferedavis completehistologicalresolutionofcollagenoussprue AT dannymmyers completehistologicalresolutionofcollagenoussprue |