Subtle concentration changes in zinc hold the key to fibrillation of α-synuclein: an updated insight on the micronutrient’s role in prevention of neurodegenerative disorders

Subtle concentration changes in zinc hold the key to fibrillation of α-synuclein: an updated insight on the micronutrient’s role in prevention of neurodegenerative disorders

Misfolded proteins have been found to be at the core of an increasing number of cognitive ailments. α-synuclein, a resident chaperone of the neurosynaptic cleft has been implicated in a major share of these neurodegenerative diseases. Over the years, a daunting task for researchers has been the iden...

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Bibliographic Details
Main Authors: Samudra Prosad Banik, Debasis Bagchi, Pradipta Banerjee, Sanjoy Chakraborty, Manashi Bagchi, Chaitali Bose, Debasmita De, Sreemoyee Saha, Sudipta Chakraborty
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
neurodegenerative disorders
α-synuclein
synucleinopathies
Parkinson’s disease
liquid-liquid phase separation
zinc as micronutrient
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1603364/full
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