Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams
Summary: The basolateral amygdala (BLA) projects to many brain regions through which it influences multiple functions. However, there is disagreement regarding the extent to which BLA axons collateralize. Using viral tracing, we found that distinct groups of BLA neurons send axon collaterals to diff...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225013501 |
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| author | Ian T. Kim Icnelia Huerta-Ocampo Osmalyn Urena Ryo Yamamoto Denis Paré |
| author_facet | Ian T. Kim Icnelia Huerta-Ocampo Osmalyn Urena Ryo Yamamoto Denis Paré |
| author_sort | Ian T. Kim |
| collection | DOAJ |
| description | Summary: The basolateral amygdala (BLA) projects to many brain regions through which it influences multiple functions. However, there is disagreement regarding the extent to which BLA axons collateralize. Using viral tracing, we found that distinct groups of BLA neurons send axon collaterals to different subsets of targets. A first group of BLA neurons projects to a hitherto underestimated combination of cortical and subcortical regions that regulate habitual or motivated behaviors, attention control, energy homeostasis, and olfactory processing. A second group of BLA neurons targets subcortical structures implicated in the genesis of defensive behaviors. By contrast, BLA neurons targeting cortical areas that support memory (hippocampus, rhinal cortices) collateralize sparingly. Overall, these results indicate that the BLA contains different clusters of neurons that contribute branching axons to distinct arrays of largely non-overlapping targets. These results impose a revision of how we conceptualize the BLA’s coordination with, and influence over, its targets. |
| format | Article |
| id | doaj-art-24a8db441d8042738369e01575f5ed56 |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-24a8db441d8042738369e01575f5ed562025-08-20T03:02:36ZengElsevieriScience2589-00422025-08-0128811308910.1016/j.isci.2025.113089Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streamsIan T. Kim0Icnelia Huerta-Ocampo1Osmalyn Urena2Ryo Yamamoto3Denis Paré4Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USACenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USACenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USACenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA; Department of Physiology, Kanazawa Medical University, Ishikawa 920-0293, JapanCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA; CorrespondenceSummary: The basolateral amygdala (BLA) projects to many brain regions through which it influences multiple functions. However, there is disagreement regarding the extent to which BLA axons collateralize. Using viral tracing, we found that distinct groups of BLA neurons send axon collaterals to different subsets of targets. A first group of BLA neurons projects to a hitherto underestimated combination of cortical and subcortical regions that regulate habitual or motivated behaviors, attention control, energy homeostasis, and olfactory processing. A second group of BLA neurons targets subcortical structures implicated in the genesis of defensive behaviors. By contrast, BLA neurons targeting cortical areas that support memory (hippocampus, rhinal cortices) collateralize sparingly. Overall, these results indicate that the BLA contains different clusters of neurons that contribute branching axons to distinct arrays of largely non-overlapping targets. These results impose a revision of how we conceptualize the BLA’s coordination with, and influence over, its targets.http://www.sciencedirect.com/science/article/pii/S2589004225013501NeuroscienceSystems neuroscienceNeuroanatomy |
| spellingShingle | Ian T. Kim Icnelia Huerta-Ocampo Osmalyn Urena Ryo Yamamoto Denis Paré Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams iScience Neuroscience Systems neuroscience Neuroanatomy |
| title | Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams |
| title_full | Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams |
| title_fullStr | Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams |
| title_full_unstemmed | Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams |
| title_short | Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams |
| title_sort | collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams |
| topic | Neuroscience Systems neuroscience Neuroanatomy |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225013501 |
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