Optimizing extracellular matrix for endothelial differentiation using a design of experiments approach

Abstract The extracellular matrix (ECM) plays a vital role in stem cell differentiation to endothelial cells in vivo and is also important for the specification of endothelial cells in vitro. Individual ECM components have previously been shown to support endothelial differentiation; here, we use a...

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Bibliographic Details
Main Authors: Mikayla L. Hall, Wei-Han Lin, Brenda M. Ogle
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-09256-9
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