The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes. PPARs have been implicated in the regulation of innate immunity, glucose and lipid metabolism, cell proliferation, wound healing, and f...
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MDPI AG
2024-10-01
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| Online Access: | https://www.mdpi.com/2073-4409/13/20/1688 |
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| author | Edit Posta Istvan Fekete Istvan Varkonyi Eva Zold Zsolt Barta |
| author_facet | Edit Posta Istvan Fekete Istvan Varkonyi Eva Zold Zsolt Barta |
| author_sort | Edit Posta |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes. PPARs have been implicated in the regulation of innate immunity, glucose and lipid metabolism, cell proliferation, wound healing, and fibrotic processes. Some synthetic PPAR ligands are promising molecules for the treatment of inflammatory and fibrotic processes in immune-mediated intestinal diseases. Some of these are currently undergoing or have previously undergone clinical trials. Dietary PPAR ligands and changes in microbiota composition could modulate PPARs’ activation to reduce inflammatory responses in these immune-mediated diseases, based on animal models and clinical trials. This narrative review aims to summarize the role of PPARs in immune-mediated bowel diseases and their potential therapeutic use. |
| format | Article |
| id | doaj-art-24a3cef811dc4767ad9cdc77f3fafc2a |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-24a3cef811dc4767ad9cdc77f3fafc2a2025-08-20T02:11:09ZengMDPI AGCells2073-44092024-10-011320168810.3390/cells13201688The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal DiseasesEdit Posta0Istvan Fekete1Istvan Varkonyi2Eva Zold3Zsolt Barta4GI Unit, Department of Infectology, Faculty of Medicine, University of Debrecen, Bartok Bela Street 2-26, 4031 Debrecen, HungaryInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi út 138, 4032 Debrecen, HungaryGI Unit, Department of Infectology, Faculty of Medicine, University of Debrecen, Bartok Bela Street 2-26, 4031 Debrecen, HungaryDepartment of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, Móricz Zsigmond str. 22, 4032 Debrecen, HungaryGI Unit, Department of Infectology, Faculty of Medicine, University of Debrecen, Bartok Bela Street 2-26, 4031 Debrecen, HungaryPeroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes. PPARs have been implicated in the regulation of innate immunity, glucose and lipid metabolism, cell proliferation, wound healing, and fibrotic processes. Some synthetic PPAR ligands are promising molecules for the treatment of inflammatory and fibrotic processes in immune-mediated intestinal diseases. Some of these are currently undergoing or have previously undergone clinical trials. Dietary PPAR ligands and changes in microbiota composition could modulate PPARs’ activation to reduce inflammatory responses in these immune-mediated diseases, based on animal models and clinical trials. This narrative review aims to summarize the role of PPARs in immune-mediated bowel diseases and their potential therapeutic use.https://www.mdpi.com/2073-4409/13/20/1688PPARCrohn’s diseaseulcerative colitiseosinophilic gastrointestinal disordersallergic diseasesmicrobiome |
| spellingShingle | Edit Posta Istvan Fekete Istvan Varkonyi Eva Zold Zsolt Barta The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases Cells PPAR Crohn’s disease ulcerative colitis eosinophilic gastrointestinal disorders allergic diseases microbiome |
| title | The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases |
| title_full | The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases |
| title_fullStr | The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases |
| title_full_unstemmed | The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases |
| title_short | The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases |
| title_sort | versatile role of peroxisome proliferator activated receptors in immune mediated intestinal diseases |
| topic | PPAR Crohn’s disease ulcerative colitis eosinophilic gastrointestinal disorders allergic diseases microbiome |
| url | https://www.mdpi.com/2073-4409/13/20/1688 |
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