Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation
Abstract Islet transplantation offers a promising treatment for type 1 diabetes (T1D), by aiming to restore insulin production and improve glycemic control. However, T1D is compounded by impaired angiogenesis and immune dysregulation, which hinder the therapeutic potential of cell replacement strate...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411574 |
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| author | Jocelyn Nikita Campa‐Carranza Simone Capuani Ashley L. Joubert Nathanael Hernandez Tommaso Bo Octavio I. Sauceda‐Villanueva Marzia Conte Letizia Franco Marco Farina Gabrielle E. Rome Yitian Xu Junjun Zheng Lissenya B. Argueta Jean A. Niles Fotis Nikolos Corrine Ying Xuan Chua Shu‐Hsia Chen Joan E. Nichols Norma S. Kenyon Alessandro Grattoni |
| author_facet | Jocelyn Nikita Campa‐Carranza Simone Capuani Ashley L. Joubert Nathanael Hernandez Tommaso Bo Octavio I. Sauceda‐Villanueva Marzia Conte Letizia Franco Marco Farina Gabrielle E. Rome Yitian Xu Junjun Zheng Lissenya B. Argueta Jean A. Niles Fotis Nikolos Corrine Ying Xuan Chua Shu‐Hsia Chen Joan E. Nichols Norma S. Kenyon Alessandro Grattoni |
| author_sort | Jocelyn Nikita Campa‐Carranza |
| collection | DOAJ |
| description | Abstract Islet transplantation offers a promising treatment for type 1 diabetes (T1D), by aiming to restore insulin production and improve glycemic control. However, T1D is compounded by impaired angiogenesis and immune dysregulation, which hinder the therapeutic potential of cell replacement strategies. To address this, this work evaluates the proangiogenic and immunomodulatory properties of mesenchymal stem cells (MSCs) to enhance vascularization and modulate early‐stage immune rejection pathways in the context of islet allotransplantation. This work employs the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) platform, a subcutaneous vascularized implant with localized immunomodulation developed by the group. This study assesses vascularization and immune regulation provided by MSCs, aiming to improve islet survival and integration in diabetic rats while considering sex as a biological variable. These findings demonstrate that MSCs significantly enhance vascularization and modulate the local microenvironment during the peri‐transplant period. Importantly, this work discovers sex‐specific differences in both processes, which influence islet engraftment and long‐term function. |
| format | Article |
| id | doaj-art-249b7bb4be3b4141a1e27da1133712d4 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-249b7bb4be3b4141a1e27da1133712d42025-08-20T02:34:43ZengWileyAdvanced Science2198-38442025-05-011220n/an/a10.1002/advs.202411574Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet TransplantationJocelyn Nikita Campa‐Carranza0Simone Capuani1Ashley L. Joubert2Nathanael Hernandez3Tommaso Bo4Octavio I. Sauceda‐Villanueva5Marzia Conte6Letizia Franco7Marco Farina8Gabrielle E. Rome9Yitian Xu10Junjun Zheng11Lissenya B. Argueta12Jean A. Niles13Fotis Nikolos14Corrine Ying Xuan Chua15Shu‐Hsia Chen16Joan E. Nichols17Norma S. Kenyon18Alessandro Grattoni19Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USACenter for Immunotherapy Research Houston Methodist Research Institute Houston TX 77030 USACenter for Immunotherapy Research Houston Methodist Research Institute Houston TX 77030 USACenter for Tissue Engineering Houston Methodist Research Institute Houston TX 77030 USACenter for Tissue Engineering Houston Methodist Research Institute Houston TX 77030 USADepartment of Urology Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USACenter for Immunotherapy Research Houston Methodist Research Institute Houston TX 77030 USACenter for Tissue Engineering Houston Methodist Research Institute Houston TX 77030 USADiabetes Research Institute University of Miami Miami FL 33136 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USAAbstract Islet transplantation offers a promising treatment for type 1 diabetes (T1D), by aiming to restore insulin production and improve glycemic control. However, T1D is compounded by impaired angiogenesis and immune dysregulation, which hinder the therapeutic potential of cell replacement strategies. To address this, this work evaluates the proangiogenic and immunomodulatory properties of mesenchymal stem cells (MSCs) to enhance vascularization and modulate early‐stage immune rejection pathways in the context of islet allotransplantation. This work employs the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) platform, a subcutaneous vascularized implant with localized immunomodulation developed by the group. This study assesses vascularization and immune regulation provided by MSCs, aiming to improve islet survival and integration in diabetic rats while considering sex as a biological variable. These findings demonstrate that MSCs significantly enhance vascularization and modulate the local microenvironment during the peri‐transplant period. Importantly, this work discovers sex‐specific differences in both processes, which influence islet engraftment and long‐term function.https://doi.org/10.1002/advs.202411574immunomodulationislet engraftmentmesenchymal stem cellssex‐specific differencesType 1 diabetesvascularized subcutaneous microenvironment |
| spellingShingle | Jocelyn Nikita Campa‐Carranza Simone Capuani Ashley L. Joubert Nathanael Hernandez Tommaso Bo Octavio I. Sauceda‐Villanueva Marzia Conte Letizia Franco Marco Farina Gabrielle E. Rome Yitian Xu Junjun Zheng Lissenya B. Argueta Jean A. Niles Fotis Nikolos Corrine Ying Xuan Chua Shu‐Hsia Chen Joan E. Nichols Norma S. Kenyon Alessandro Grattoni Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation Advanced Science immunomodulation islet engraftment mesenchymal stem cells sex‐specific differences Type 1 diabetes vascularized subcutaneous microenvironment |
| title | Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation |
| title_full | Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation |
| title_fullStr | Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation |
| title_full_unstemmed | Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation |
| title_short | Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation |
| title_sort | immune and angiogenic profiling of mesenchymal stem cell functions in a subcutaneous microenvironment for allogeneic islet transplantation |
| topic | immunomodulation islet engraftment mesenchymal stem cells sex‐specific differences Type 1 diabetes vascularized subcutaneous microenvironment |
| url | https://doi.org/10.1002/advs.202411574 |
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