The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report
Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis. Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta-analysis and two randomized clinical trials are obt...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2015-12-01
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| Series: | Acta Medica Indonesiana |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/29 |
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| _version_ | 1850099032033067008 |
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| author | Indra Wijaya |
| author_facet | Indra Wijaya |
| author_sort | Indra Wijaya |
| collection | DOAJ |
| description |
Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis. Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta-analysis and two randomized clinical trials are obtained. Through critical appraisal, it was concluded that the articles meet the criteria for validity and relevance. Results: the article found that there is a positive effect of ursodeoxycholic acid on the activity of serum transaminases and cholestasis indexes. However, there is insufficient evidence to support or to refute effects of ursodeoxycholic acid on disease’s course as well as the viral load. Conclusion: better method of clinical trials are needed to obtain a valid and applicable result for daily practice.
Key words: ursodeoxycholic acid, acute viral hepatitis
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| format | Article |
| id | doaj-art-249afd3dbe4e4f69b028187e2e954a44 |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-249afd3dbe4e4f69b028187e2e954a442025-08-20T02:40:35ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322015-12-01474The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case ReportIndra Wijaya0Department of Internal Medicine. Faculty of Medicine, Universitas Pelita Harapan, Banten, Indonesia Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis. Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta-analysis and two randomized clinical trials are obtained. Through critical appraisal, it was concluded that the articles meet the criteria for validity and relevance. Results: the article found that there is a positive effect of ursodeoxycholic acid on the activity of serum transaminases and cholestasis indexes. However, there is insufficient evidence to support or to refute effects of ursodeoxycholic acid on disease’s course as well as the viral load. Conclusion: better method of clinical trials are needed to obtain a valid and applicable result for daily practice. Key words: ursodeoxycholic acid, acute viral hepatitis https://actamedindones.org/index.php/ijim/article/view/29 |
| spellingShingle | Indra Wijaya The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report Acta Medica Indonesiana |
| title | The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report |
| title_full | The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report |
| title_fullStr | The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report |
| title_full_unstemmed | The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report |
| title_short | The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report |
| title_sort | role of ursodeoxycholic acid in acute viral hepatitis an evidence based case report |
| url | https://actamedindones.org/index.php/ijim/article/view/29 |
| work_keys_str_mv | AT indrawijaya theroleofursodeoxycholicacidinacuteviralhepatitisanevidencebasedcasereport AT indrawijaya roleofursodeoxycholicacidinacuteviralhepatitisanevidencebasedcasereport |