Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory
Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a r...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2156273 |
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| author | Pedro Romero-Aroca Marc Baget-Bernaldiz Alicia Pareja-Rios Maribel Lopez-Galvez Raul Navarro-Gil Raquel Verges |
| author_facet | Pedro Romero-Aroca Marc Baget-Bernaldiz Alicia Pareja-Rios Maribel Lopez-Galvez Raul Navarro-Gil Raquel Verges |
| author_sort | Pedro Romero-Aroca |
| collection | DOAJ |
| description | Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug. |
| format | Article |
| id | doaj-art-249482b74b67403c9c38d207fde6d572 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-249482b74b67403c9c38d207fde6d5722025-02-03T01:10:30ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/21562732156273Diabetic Macular Edema Pathophysiology: Vasogenic versus InflammatoryPedro Romero-Aroca0Marc Baget-Bernaldiz1Alicia Pareja-Rios2Maribel Lopez-Galvez3Raul Navarro-Gil4Raquel Verges5Ophthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), University of Rovira & Virgili, Reus, SpainOphthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), University of Rovira & Virgili, Reus, SpainDepartment of Ophthalmology, Retina Section, Hospital Universitario de Canarias, Tenerife, SpainDepartment of Ophthalmology, University Hospital Valladolid, Ocular Diabetes Unit of IOBA, Valladolid, SpainOphthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), University of Rovira & Virgili, Reus, SpainOphthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), University of Rovira & Virgili, Reus, SpainDiabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.http://dx.doi.org/10.1155/2016/2156273 |
| spellingShingle | Pedro Romero-Aroca Marc Baget-Bernaldiz Alicia Pareja-Rios Maribel Lopez-Galvez Raul Navarro-Gil Raquel Verges Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory Journal of Diabetes Research |
| title | Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory |
| title_full | Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory |
| title_fullStr | Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory |
| title_full_unstemmed | Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory |
| title_short | Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory |
| title_sort | diabetic macular edema pathophysiology vasogenic versus inflammatory |
| url | http://dx.doi.org/10.1155/2016/2156273 |
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