Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice

Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice

Cathinone, the active principle of khat (Catha edulis), stimulates, excites and produces euphoric feelings in khat users. Locomotor and rearing activities, either individual or in groups, of male Swiss albino mice were decreased significantly compared to the control. Motor coordination tests (rotaro...

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Bibliographic Details
Main Authors: Safhi Mohammed M., Alam Mohammad Firoz, Khuwaja Gulrana, Hussain Sohail, Siddiqui Mohammed Hakeem, Islam Farah, Khardali Ibrahim, Al-Sanosi Rashad Mohammed, Alhazmi Hassan A., Khan Andleeb, Islam Fakhrul
Format: Article
Language:English
Published: Sciendo 2018-12-01
Series:Acta Pharmaceutica
Subjects:
cathinone
mice
behavioral activities
dopamine
3,4-dihydroxyphenyl acetic acid
homovanillic acid
limbic area
Online Access:https://doi.org/10.2478/acph-2018-0038
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