Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice
Cathinone, the active principle of khat (Catha edulis), stimulates, excites and produces euphoric feelings in khat users. Locomotor and rearing activities, either individual or in groups, of male Swiss albino mice were decreased significantly compared to the control. Motor coordination tests (rotaro...
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| Format: | Article |
| Language: | English |
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2018-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0038 |
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| author | Safhi Mohammed M. Alam Mohammad Firoz Khuwaja Gulrana Hussain Sohail Siddiqui Mohammed Hakeem Islam Farah Khardali Ibrahim Al-Sanosi Rashad Mohammed Alhazmi Hassan A. Khan Andleeb Islam Fakhrul |
| author_facet | Safhi Mohammed M. Alam Mohammad Firoz Khuwaja Gulrana Hussain Sohail Siddiqui Mohammed Hakeem Islam Farah Khardali Ibrahim Al-Sanosi Rashad Mohammed Alhazmi Hassan A. Khan Andleeb Islam Fakhrul |
| author_sort | Safhi Mohammed M. |
| collection | DOAJ |
| description | Cathinone, the active principle of khat (Catha edulis), stimulates, excites and produces euphoric feelings in khat users. Locomotor and rearing activities, either individual or in groups, of male Swiss albino mice were decreased significantly compared to the control. Motor coordination tests (rotarod, rope climb and grip tests) have shown decreased motor performance in the mice treated with cathinone compared to the control. The elevated plus maze test has shown significant anxiety in the mice compared to the control. Contents of dopamine and its metabolite, homovanillic acid, were increased in the limbic areas compared to the control group. In contrast, contents of 3,4-dihydroxyphenyl acetic acid were depleted significantly and dose dependently compared to the control group in the limbic areas of mice. In conclusion, natural cathinone has depleted motor coordination, accelerated anxiety in mice and altered the contents of dopamine and its metabolites. |
| format | Article |
| id | doaj-art-2493143a995f456992fd4ad6c6aa099b |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-2493143a995f456992fd4ad6c6aa099b2025-02-02T11:49:57ZengSciendoActa Pharmaceutica1846-95582018-12-0168448549510.2478/acph-2018-0038acph-2018-0038Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino MiceSafhi Mohammed M.0Alam Mohammad Firoz1Khuwaja Gulrana2Hussain Sohail3Siddiqui Mohammed Hakeem4Islam Farah5Khardali Ibrahim6Al-Sanosi Rashad Mohammed7Alhazmi Hassan A.8Khan Andleeb9Islam Fakhrul10Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaPoison Control and Medical Forensic Chemistry Center, Ministry of Health Jazan,Jazan, Kingdom of Saudi ArabiaSubstance Abuse Research Center, Jazan University, Ministry of Education,Jazan, Kingdom of Saudi ArabiaSubstance Abuse Research Center, Jazan University, Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaNeuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education,Jazan, Kingdom of Saudi ArabiaCathinone, the active principle of khat (Catha edulis), stimulates, excites and produces euphoric feelings in khat users. Locomotor and rearing activities, either individual or in groups, of male Swiss albino mice were decreased significantly compared to the control. Motor coordination tests (rotarod, rope climb and grip tests) have shown decreased motor performance in the mice treated with cathinone compared to the control. The elevated plus maze test has shown significant anxiety in the mice compared to the control. Contents of dopamine and its metabolite, homovanillic acid, were increased in the limbic areas compared to the control group. In contrast, contents of 3,4-dihydroxyphenyl acetic acid were depleted significantly and dose dependently compared to the control group in the limbic areas of mice. In conclusion, natural cathinone has depleted motor coordination, accelerated anxiety in mice and altered the contents of dopamine and its metabolites.https://doi.org/10.2478/acph-2018-0038cathinonemicebehavioral activitiesdopamine3,4-dihydroxyphenyl acetic acidhomovanillic acidlimbic area |
| spellingShingle | Safhi Mohammed M. Alam Mohammad Firoz Khuwaja Gulrana Hussain Sohail Siddiqui Mohammed Hakeem Islam Farah Khardali Ibrahim Al-Sanosi Rashad Mohammed Alhazmi Hassan A. Khan Andleeb Islam Fakhrul Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice Acta Pharmaceutica cathinone mice behavioral activities dopamine 3,4-dihydroxyphenyl acetic acid homovanillic acid limbic area |
| title | Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice |
| title_full | Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice |
| title_fullStr | Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice |
| title_full_unstemmed | Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice |
| title_short | Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice |
| title_sort | catha edulis active principle cathinone suppresses motor coordination accelerates anxiety and alters the levels of dopamine and its metabolites in the limbic areas of male swiss albino mice |
| topic | cathinone mice behavioral activities dopamine 3,4-dihydroxyphenyl acetic acid homovanillic acid limbic area |
| url | https://doi.org/10.2478/acph-2018-0038 |
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