HIV Infection and TLR Signalling in the Liver
Despite the availability of effective combination antiretroviral therapy (cART), liver disease is one of the leading causes of morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals, specifically, in the presence of viral hepatitis coinfection. HIV, a single stranded RNA...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/473925 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554691434643456 |
|---|---|
| author | Megan Crane Kumar Visvanathan Sharon R. Lewin |
| author_facet | Megan Crane Kumar Visvanathan Sharon R. Lewin |
| author_sort | Megan Crane |
| collection | DOAJ |
| description | Despite the availability of effective combination antiretroviral therapy (cART), liver disease is one of the leading causes of morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals, specifically, in the presence of viral hepatitis coinfection. HIV, a single stranded RNA virus, can bind to and activate both Toll-like receptor (TLR)7 and TLR8 in circulating blood mononuclear cells, but little is known about the effect of HIV on TLRs expressed in the liver. HIV can directly infect cells of the liver and HIV-mediated depletion of CD4+ T-cells in the gastrointestinal tract (GI tract) results in increased circulating lipopolysaccharide (LPS), both of which may impact on TLR signaling in the liver and subsequent liver disease progression. The potential direct and indirect effects of HIV on TLR signaling in the liver will be explored in this paper. |
| format | Article |
| id | doaj-art-2490ff9245b740739e23528e648de7d0 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-2490ff9245b740739e23528e648de7d02025-02-03T05:50:46ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/473925473925HIV Infection and TLR Signalling in the LiverMegan Crane0Kumar Visvanathan1Sharon R. Lewin2Department of Medicine, Monash University, Melbourne, VIC, AustraliaDepartment of Medicine, Monash Medical Centre, Melbourne, VIC, AustraliaDepartment of Medicine, Monash University, Melbourne, VIC, AustraliaDespite the availability of effective combination antiretroviral therapy (cART), liver disease is one of the leading causes of morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals, specifically, in the presence of viral hepatitis coinfection. HIV, a single stranded RNA virus, can bind to and activate both Toll-like receptor (TLR)7 and TLR8 in circulating blood mononuclear cells, but little is known about the effect of HIV on TLRs expressed in the liver. HIV can directly infect cells of the liver and HIV-mediated depletion of CD4+ T-cells in the gastrointestinal tract (GI tract) results in increased circulating lipopolysaccharide (LPS), both of which may impact on TLR signaling in the liver and subsequent liver disease progression. The potential direct and indirect effects of HIV on TLR signaling in the liver will be explored in this paper.http://dx.doi.org/10.1155/2012/473925 |
| spellingShingle | Megan Crane Kumar Visvanathan Sharon R. Lewin HIV Infection and TLR Signalling in the Liver Gastroenterology Research and Practice |
| title | HIV Infection and TLR Signalling in the Liver |
| title_full | HIV Infection and TLR Signalling in the Liver |
| title_fullStr | HIV Infection and TLR Signalling in the Liver |
| title_full_unstemmed | HIV Infection and TLR Signalling in the Liver |
| title_short | HIV Infection and TLR Signalling in the Liver |
| title_sort | hiv infection and tlr signalling in the liver |
| url | http://dx.doi.org/10.1155/2012/473925 |
| work_keys_str_mv | AT megancrane hivinfectionandtlrsignallingintheliver AT kumarvisvanathan hivinfectionandtlrsignallingintheliver AT sharonrlewin hivinfectionandtlrsignallingintheliver |