Cardiac injury caused by iron overload in thalassemia
Cardiac iron overload affects approximately 25% of patients with β-thalassemia major, which is associated with increased morbidity and mortality. Two mechanisms are responsible for iron overload in β-thalassemia: increased iron absorption due to ineffective erythropoiesis and blood transfusions. Thi...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1514722/full |
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| author | Chunxi Fu Chunxi Fu Xue Yang Xue Yang |
| author_facet | Chunxi Fu Chunxi Fu Xue Yang Xue Yang |
| author_sort | Chunxi Fu |
| collection | DOAJ |
| description | Cardiac iron overload affects approximately 25% of patients with β-thalassemia major, which is associated with increased morbidity and mortality. Two mechanisms are responsible for iron overload in β-thalassemia: increased iron absorption due to ineffective erythropoiesis and blood transfusions. This review examines the mechanisms of myocardial injury caused by cardiac iron overload and role of various clinical examination techniques in assessing cardiac iron burden and functional impairment. Early identification and intervention for cardiac injury and iron overload in β-thalassemia have the potential to prevent and reverse or delay its progression in the early stages, playing a crucial role in its prognosis. |
| format | Article |
| id | doaj-art-248233e51c0f40b68bd17f38d70e099d |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-248233e51c0f40b68bd17f38d70e099d2025-01-27T06:40:23ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.15147221514722Cardiac injury caused by iron overload in thalassemiaChunxi Fu0Chunxi Fu1Xue Yang2Xue Yang3Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, ChinaCardiac iron overload affects approximately 25% of patients with β-thalassemia major, which is associated with increased morbidity and mortality. Two mechanisms are responsible for iron overload in β-thalassemia: increased iron absorption due to ineffective erythropoiesis and blood transfusions. This review examines the mechanisms of myocardial injury caused by cardiac iron overload and role of various clinical examination techniques in assessing cardiac iron burden and functional impairment. Early identification and intervention for cardiac injury and iron overload in β-thalassemia have the potential to prevent and reverse or delay its progression in the early stages, playing a crucial role in its prognosis.https://www.frontiersin.org/articles/10.3389/fped.2025.1514722/fullβ-thalassemiairon overloadmyocardial injurytreatmentearly identification |
| spellingShingle | Chunxi Fu Chunxi Fu Xue Yang Xue Yang Cardiac injury caused by iron overload in thalassemia Frontiers in Pediatrics β-thalassemia iron overload myocardial injury treatment early identification |
| title | Cardiac injury caused by iron overload in thalassemia |
| title_full | Cardiac injury caused by iron overload in thalassemia |
| title_fullStr | Cardiac injury caused by iron overload in thalassemia |
| title_full_unstemmed | Cardiac injury caused by iron overload in thalassemia |
| title_short | Cardiac injury caused by iron overload in thalassemia |
| title_sort | cardiac injury caused by iron overload in thalassemia |
| topic | β-thalassemia iron overload myocardial injury treatment early identification |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1514722/full |
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