Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization
Anti-M antibody is one of the causes of severe fetal anemia and intrauterine death despite its relatively low frequency. A G3P2 26-year-old pregnant woman referred to our hospital at 29 weeks gestational age (WGA) with fetal hydrops. Her second pregnancy results in intrauterine fetal death at 35 WGA...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_60_22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841554820940431360 |
|---|---|
| author | Rachmat Dediat Kapnosa Hasani Gatot Abdurazak Adhi Pribadi |
| author_facet | Rachmat Dediat Kapnosa Hasani Gatot Abdurazak Adhi Pribadi |
| author_sort | Rachmat Dediat Kapnosa Hasani |
| collection | DOAJ |
| description | Anti-M antibody is one of the causes of severe fetal anemia and intrauterine death despite its relatively low frequency. A G3P2 26-year-old pregnant woman referred to our hospital at 29 weeks gestational age (WGA) with fetal hydrops. Her second pregnancy results in intrauterine fetal death at 35 WGA due to fetal hydrops. From ultrasound exam, we found singleton live fetus with ascites, cardiomegaly, and pericardial effusion. The peak systolic velocity in the fetal middle cerebral artery (PSV-MCA) was 1.44 multiples of the median corresponding to fetal anemia. The patient’s blood group was B RhD+M− N+. A reactive IgG anti-M antibody was detected at 37°C. Fetal hemoglobin (Hb) from the first cordocentesis was 2.2 g/dl and we perform multiple intrauterine transfusions and cesarean section at 34 WGA. The postdelivery Hb level was 10.2 g/dl and infant need three times packed red blood cell transfusions after delivery. |
| format | Article |
| id | doaj-art-2480f0cc81c841ec8d1208205a24af60 |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-2480f0cc81c841ec8d1208205a24af602025-01-08T09:10:37ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652024-12-0118232332510.4103/ajts.ajts_60_22Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunizationRachmat Dediat Kapnosa HasaniGatot AbdurazakAdhi PribadiAnti-M antibody is one of the causes of severe fetal anemia and intrauterine death despite its relatively low frequency. A G3P2 26-year-old pregnant woman referred to our hospital at 29 weeks gestational age (WGA) with fetal hydrops. Her second pregnancy results in intrauterine fetal death at 35 WGA due to fetal hydrops. From ultrasound exam, we found singleton live fetus with ascites, cardiomegaly, and pericardial effusion. The peak systolic velocity in the fetal middle cerebral artery (PSV-MCA) was 1.44 multiples of the median corresponding to fetal anemia. The patient’s blood group was B RhD+M− N+. A reactive IgG anti-M antibody was detected at 37°C. Fetal hemoglobin (Hb) from the first cordocentesis was 2.2 g/dl and we perform multiple intrauterine transfusions and cesarean section at 34 WGA. The postdelivery Hb level was 10.2 g/dl and infant need three times packed red blood cell transfusions after delivery.https://journals.lww.com/10.4103/ajts.ajts_60_22anti-m alloimmunizationfetal anemiahydrops fetalisintrauterine transfusion |
| spellingShingle | Rachmat Dediat Kapnosa Hasani Gatot Abdurazak Adhi Pribadi Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization Asian Journal of Transfusion Science anti-m alloimmunization fetal anemia hydrops fetalis intrauterine transfusion |
| title | Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization |
| title_full | Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization |
| title_fullStr | Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization |
| title_full_unstemmed | Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization |
| title_short | Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization |
| title_sort | serial intrauterine transfusion for severe fetal anemia due to anti m alloimmunization |
| topic | anti-m alloimmunization fetal anemia hydrops fetalis intrauterine transfusion |
| url | https://journals.lww.com/10.4103/ajts.ajts_60_22 |
| work_keys_str_mv | AT rachmatdediatkapnosahasani serialintrauterinetransfusionforseverefetalanemiaduetoantimalloimmunization AT gatotabdurazak serialintrauterinetransfusionforseverefetalanemiaduetoantimalloimmunization AT adhipribadi serialintrauterinetransfusionforseverefetalanemiaduetoantimalloimmunization |