Water-Mediated Synthesis of (<i>E</i>)-3-(1-Methyl-1<i>H</i>-benzo[<i>d</i>]imidazol-5-yl)-<i>N</i>-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue

Water-Mediated Synthesis of (<i>E</i>)-3-(1-Methyl-1<i>H</i>-benzo[<i>d</i>]imidazol-5-yl)-<i>N</i>-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue

Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with diverse biological activities, notably anticancer properties. However, its ester group is metabolically unstable. The amide derivative, CAPA, offers improved metabolic stability to esterases but still possesses a metabolically li...

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Bibliographic Details
Main Authors:	Muppidi Subbarao, Sean M. Kerwin
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Molbank
Subjects:	anticancer natural product CAPA Wittig reaction water-mediated synthesis
Online Access:	https://www.mdpi.com/1422-8599/2024/4/M1915
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