PD-1 deficiency disrupts in vivo neural activity in mouse Hippocampus and cortex

PD-1 deficiency disrupts in vivo neural activity in mouse Hippocampus and cortex

Programmed cell death 1 (PD-1), encoded by the Pdcd1 gene, was identified as a target in cancer immunotherapy but may result in the overactivation of T cell function and emotional changes such as anxiety. The dynamic changes in neuronal activity related to the anxious status caused by Pdcd1−/− remai...

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Bibliographic Details
Main Authors: Minghui Hu, Cui Lv, Jianping Zhu, Hao Zhang, Xinyu Wang, Luyan You, Jinlu Xie, Wei Liu, Xiaocen Wei, Kai Chen, Zifa Li, Sheng Wei, Xiwen Geng
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Programmed cell death 1
Anxiety
Spike
Local field potential
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002189
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