Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology
Hematology patients are at high risk of nosocomial infections, necessitating rapid and reliable bacterial detection. Current methods, such as culture and polymerase chain reaction (PCR), are often slow, expensive, or susceptible to contamination. This research introduces a novel bio-based superhydro...
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| Format: | Article |
| Language: | English |
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Kaunas University of Technology
2025-06-01
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| Series: | Medžiagotyra |
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| Online Access: | https://matsc.ktu.lt/index.php/MatSc/article/view/40980 |
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| author | Lifen LAN Xiaoxiao LU |
| author_facet | Lifen LAN Xiaoxiao LU |
| author_sort | Lifen LAN |
| collection | DOAJ |
| description | Hematology patients are at high risk of nosocomial infections, necessitating rapid and reliable bacterial detection. Current methods, such as culture and polymerase chain reaction (PCR), are often slow, expensive, or susceptible to contamination. This research introduces a novel bio-based superhydrophobic sensor to address these limitations. The sensor utilizes a polydimethylsiloxane (PDMS) and TiO2 coated substrate to create a superhydrophobic surface (water contact angle >150°), which significantly reduces bacterial adhesion. Detection relies on peptides that undergo a conformational change upon binding specific bacteria, releasing attached magnetic beads. These beads are detected electrochemically using an indium tin oxide (ITO) electrode modified with cadmium telluride (CdTe) quantum dots and graphene oxide (GO) composite, enhancing electron transfer efficiency by 2.3-fold compared with bare ITO. This design achieved rapid (<90 minutes) and sensitive detection. The sensor had high accuracy comparable to PCR and discriminated between Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. aeruginosa). By combining anti-fouling properties with specific bacterial recognition and enhanced electrochemical detection, this sensor offers a promising platform for reducing infection risks in hematology. |
| format | Article |
| id | doaj-art-246d64d30f64407983f5961fd6efea9d |
| institution | Kabale University |
| issn | 1392-1320 2029-7289 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Kaunas University of Technology |
| record_format | Article |
| series | Medžiagotyra |
| spelling | doaj-art-246d64d30f64407983f5961fd6efea9d2025-08-20T03:25:15ZengKaunas University of TechnologyMedžiagotyra1392-13202029-72892025-06-0110.5755/j02.ms.4098046234Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in HematologyLifen LAN0https://orcid.org/0009-0008-0478-1015Xiaoxiao LU1https://orcid.org/0009-0000-1088-5293Affiliated Hospital of Inner Mongolia Medical UniversityChongqing University Cancer HospitalHematology patients are at high risk of nosocomial infections, necessitating rapid and reliable bacterial detection. Current methods, such as culture and polymerase chain reaction (PCR), are often slow, expensive, or susceptible to contamination. This research introduces a novel bio-based superhydrophobic sensor to address these limitations. The sensor utilizes a polydimethylsiloxane (PDMS) and TiO2 coated substrate to create a superhydrophobic surface (water contact angle >150°), which significantly reduces bacterial adhesion. Detection relies on peptides that undergo a conformational change upon binding specific bacteria, releasing attached magnetic beads. These beads are detected electrochemically using an indium tin oxide (ITO) electrode modified with cadmium telluride (CdTe) quantum dots and graphene oxide (GO) composite, enhancing electron transfer efficiency by 2.3-fold compared with bare ITO. This design achieved rapid (<90 minutes) and sensitive detection. The sensor had high accuracy comparable to PCR and discriminated between Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. aeruginosa). By combining anti-fouling properties with specific bacterial recognition and enhanced electrochemical detection, this sensor offers a promising platform for reducing infection risks in hematology.https://matsc.ktu.lt/index.php/MatSc/article/view/40980bio-basedsuperhydrophobichematologyanti-foulingbacterial detectionelectrochemical sensorpeptidequantum dots |
| spellingShingle | Lifen LAN Xiaoxiao LU Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology Medžiagotyra bio-based superhydrophobic hematology anti-fouling bacterial detection electrochemical sensor peptide quantum dots |
| title | Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology |
| title_full | Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology |
| title_fullStr | Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology |
| title_full_unstemmed | Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology |
| title_short | Bio-based Superhydrophobic Sensor for Enhanced Anti-Fouling and Rapid Bacterial Detection in Hematology |
| title_sort | bio based superhydrophobic sensor for enhanced anti fouling and rapid bacterial detection in hematology |
| topic | bio-based superhydrophobic hematology anti-fouling bacterial detection electrochemical sensor peptide quantum dots |
| url | https://matsc.ktu.lt/index.php/MatSc/article/view/40980 |
| work_keys_str_mv | AT lifenlan biobasedsuperhydrophobicsensorforenhancedantifoulingandrapidbacterialdetectioninhematology AT xiaoxiaolu biobasedsuperhydrophobicsensorforenhancedantifoulingandrapidbacterialdetectioninhematology |