Influence of dopaminergically mediated reward on somatosensory decision-making.
<h4>Unlabelled</h4>Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli o...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-07-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000164&type=printable |
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| author | Burkhard Pleger Christian C Ruff Felix Blankenburg Stefan Klöppel Jon Driver Raymond J Dolan |
| author_facet | Burkhard Pleger Christian C Ruff Felix Blankenburg Stefan Klöppel Jon Driver Raymond J Dolan |
| author_sort | Burkhard Pleger |
| collection | DOAJ |
| description | <h4>Unlabelled</h4>Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being rewarded for correct performance at trial end via a visual signal, at one of four anticipated financial levels. Prior to the procedure, participants received either placebo (saline), a dopamine agonist (levodopa), or an antagonist (haloperidol).<h4>Principal findings</h4>higher anticipated reward improved tactile decisions. Visually signalled reward reactivated primary somatosensory cortex for the judged hand, more strongly for higher reward. After receiving a higher reward on one trial, somatosensory activations and decisions were enhanced on the next trial. These behavioural and neural effects were all enhanced by levodopa and attenuated by haloperidol, indicating dopaminergic dependency. Dopaminergic reward-related influences extend even to early somatosensory cortex and sensory decision-making. |
| format | Article |
| id | doaj-art-246955c38d05487591183246058566a1 |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2009-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-246955c38d05487591183246058566a12025-08-20T03:22:35ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852009-07-0177e100016410.1371/journal.pbio.1000164Influence of dopaminergically mediated reward on somatosensory decision-making.Burkhard PlegerChristian C RuffFelix BlankenburgStefan KlöppelJon DriverRaymond J Dolan<h4>Unlabelled</h4>Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being rewarded for correct performance at trial end via a visual signal, at one of four anticipated financial levels. Prior to the procedure, participants received either placebo (saline), a dopamine agonist (levodopa), or an antagonist (haloperidol).<h4>Principal findings</h4>higher anticipated reward improved tactile decisions. Visually signalled reward reactivated primary somatosensory cortex for the judged hand, more strongly for higher reward. After receiving a higher reward on one trial, somatosensory activations and decisions were enhanced on the next trial. These behavioural and neural effects were all enhanced by levodopa and attenuated by haloperidol, indicating dopaminergic dependency. Dopaminergic reward-related influences extend even to early somatosensory cortex and sensory decision-making.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000164&type=printable |
| spellingShingle | Burkhard Pleger Christian C Ruff Felix Blankenburg Stefan Klöppel Jon Driver Raymond J Dolan Influence of dopaminergically mediated reward on somatosensory decision-making. PLoS Biology |
| title | Influence of dopaminergically mediated reward on somatosensory decision-making. |
| title_full | Influence of dopaminergically mediated reward on somatosensory decision-making. |
| title_fullStr | Influence of dopaminergically mediated reward on somatosensory decision-making. |
| title_full_unstemmed | Influence of dopaminergically mediated reward on somatosensory decision-making. |
| title_short | Influence of dopaminergically mediated reward on somatosensory decision-making. |
| title_sort | influence of dopaminergically mediated reward on somatosensory decision making |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000164&type=printable |
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